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- H-L-Val-OEt·HCl
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2026-09-11
- CAS:17609-47-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | Ethyl L-valinate hydrochloride Basic information |
| | Ethyl L-valinate hydrochloride Chemical Properties |
| Melting point | 102-105 °C(lit.) | | alpha | 7 º (c=2, H2O) | | storage temp. | Sealed in dry,Room Temperature | | Water Solubility | Soluble in water | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | powder to crystal | | color | White to Almost white | | Optical Rotation | [α]20/D +6.7°, c = 2 in H2O | | Major Application | peptide synthesis | | InChI | InChI=1/C7H15NO2.ClH/c1-4-10-7(9)6(8)5(2)3;/h5-6H,4,8H2,1-3H3;1H/t6-;/s3 | | InChIKey | PQGVTLQEKCJXKF-RGMNGODLSA-N | | SMILES | [C@H](N)(C(C)C)C(=O)OCC.Cl |&1:0,r| | | CAS DataBase Reference | 17609-47-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29224999 | | Storage Class | 11 - Combustible Solids |
| | Ethyl L-valinate hydrochloride Usage And Synthesis |
| Chemical Properties | white crystalline powder | | Uses | peptide synthesis | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | The general procedure for the synthesis of L-valine ethyl ester hydrochloride from ethanol and L-valine is as follows: 5 kg (42.7 mol) of L-valine and 4 kg of anhydrous ethanol were added to a 50-liter glass reactor and stirred until complete dissolution. After cooling the reaction mixture to 0-10°C, 8.8 liters of thionyl chloride were added slowly and dropwise. After the dropwise addition was completed, the reaction mixture was gradually heated to reflux and the reaction was maintained for 18 hours. Upon completion of the reaction, the reaction solution was concentrated to dryness. Subsequently, 15 liters of isopropyl acetate was added to the dried residue at 15 to 20°C and stirred for 1 hour. Finally, the product was collected by diafiltration to give 6.1 kg of off-white solid, Intermediate 1 (where R1 is ethyl). | | References | [1] Tetrahedron, 2005, vol. 61, # 35, p. 8423 - 8442
[2] Journal of the Indian Chemical Society, 2001, vol. 78, # 3, p. 137 - 141
[3] Journal of the American Chemical Society, 2018, vol. 140, # 22, p. 6818 - 6822
[4] Chemistry of Natural Compounds, 1994, vol. 30, # 2, p. 238 - 244
[5] Khimiya Prirodnykh Soedinenii, 1994, # 2, p. 261 - 268 |
| | Ethyl L-valinate hydrochloride Preparation Products And Raw materials |
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