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| | Ethyl propionylacetate Basic information |
| | Ethyl propionylacetate Chemical Properties |
| Melting point | 98 °C | | Boiling point | 83-84 °C/12 mmHg (lit.) | | density | 1.012 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.422(lit.) | | Fp | 172 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Miscible with glacial acetic acid. | | form | Liquid | | pka | 10.58±0.46(Predicted) | | Specific Gravity | 1.01 | | color | Clear colorless to pale yellow | | BRN | 970270 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. | | InChI | 1S/C7H12O3/c1-3-6(8)5-7(9)10-4-2/h3-5H2,1-2H3 | | InChIKey | UDRCONFHWYGWFI-UHFFFAOYSA-N | | SMILES | CCOC(=O)CC(=O)CC | | CAS DataBase Reference | 4949-44-4(CAS DataBase Reference) | | NIST Chemistry Reference | Ethyl propionylacetate(4949-44-4) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | TSCA | T | | HazardClass | IRRITANT | | HS Code | 29183000 | | Storage Class | 10 - Combustible liquids |
| | Ethyl propionylacetate Usage And Synthesis |
| Chemical Properties | colourless liquid | | Uses | An intermediate of Rosuvastatin. | | Uses | Ethyl propionylacetate acts as a precursor used in the preparation of 1-ethyl- and 1-n-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid bearing one or two substituents on the benzene ring. Further, it is used to prepare 3-propionyl-2H-cyclohepta[b]furan-2-one. | | Uses | Ethyl propionylacetate has been used in the synthesis of 1-ethyl- and 1-n-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid bearing one or two substituents on the benzene ring. | | Synthesis Reference(s) | Synthesis, p. 829, 1978 DOI: 10.1055/s-1978-24903 | | General Description | Ethyl propionylacetate reacts with tropolone p-toluenesulfonate in the presence of sodium ethoxide to give 3-propionyl-2H-cyclohepta[b]furan-2-one. |
| | Ethyl propionylacetate Preparation Products And Raw materials |
| Raw materials | TRIPHENYLMETHYL SODIUM-->2,2-diMethyl-5-propanoyl-1,3-dioxane-4,6-dione-->Pentanoic acid, 2-diazo-3-hydroxy-, ethyl ester-->2-Oxazolidinone, 3-(1-oxopropyl)--->Carbon tetrachloride-->Iodomethane-->Ethyl acetate-->3-Propionylthiazolidine-2-thione-->Propionyl chloride-->Pentanoic acid,3-hydroxy-, ethyl ester-->3,5-Dimethyl-1-(1-Oxopropyl)-1H-Pyrazole-->4-Pentenoic acid, 3-hydroxy-, ethyl ester-->2,2-Dimethyl-1,3-dioxane-4,6-dione-->Diethyl malonate | | Preparation Products | Etodolac-->ETHYL 4-FLUORO-3-OXOPENTANOATE |
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