E3 Ligase Ligand-Linker Conjugates 1 manufacturers
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| | E3 Ligase Ligand-Linker Conjugates 1 Basic information |
| Product Name: | E3 Ligase Ligand-Linker Conjugates 1 | | Synonyms: | E3 Ligase Ligand-Linker Conjugates 1;E3 Ligase Ligand-Linker Conjugate 1;2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid;Cereblon Ligand -Linker Conjugates 1;Acetic acid, 2-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-;14-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihy
dro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetra
decanoic acid;4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecan-1-oic acid;14-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxatetradecan-1-oic acid | | CAS: | 2097938-44-6 | | MF: | C23H29N3O10 | | MW: | 507.49 | | EINECS: | | | Product Categories: | peg | | Mol File: | 2097938-44-6.mol |  |
| | E3 Ligase Ligand-Linker Conjugates 1 Chemical Properties |
| Boiling point | 769.8±60.0 °C(Predicted) | | density | 1.410±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, stored under nitrogen | | form | Oil | | pka | 3.39±0.10(Predicted) | | color | Light yellow to yellow |
| | E3 Ligase Ligand-Linker Conjugates 1 Usage And Synthesis |
| Uses | Pomalidomide-PEG4-C-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. | | IC 50 | Cereblon | | References | [1] Guangrong Zheng, et al. Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. WO2017184995A1. |
| | E3 Ligase Ligand-Linker Conjugates 1 Preparation Products And Raw materials |
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