- Sauchinone
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2026-07-27
- CAS:177931-17-8
- Purity: 99.12%
- Supply Ability: 10g
- Sauchinone
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2023-02-24
- CAS:177931-17-8
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- SAUCHINONE
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- $1.00
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2019-07-06
- CAS:177931-17-8
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 100KG
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| | SAUCHINONE Basic information |
| Product Name: | SAUCHINONE | | Synonyms: | (5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one;(5aα,7α,8β,8aβ,14aS*,14bβ)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one;Sauchinone, 98%, from Saururus chinensis (Lour. ) Baill;SAUCHINONE;(5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro- 5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one;5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one, 5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-, (5aR,7R,8S,8aR,14aS,14bR)-;Sauchinone >=98% (HPLC);AI3 00896 | | CAS: | 177931-17-8 | | MF: | C20H20O6 | | MW: | 356.37 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 177931-17-8.mol |  |
| | SAUCHINONE Chemical Properties |
| Melting point | 224-226℃ | | Boiling point | 498.1±45.0 °C(Predicted) | | density | 1.43±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | form | powder | | color | white to beige | | InChI | 1S/C20H20O6/c1-9-3-11-13(21)5-17-20(25-8-24-17)19(11)18(10(9)2)12-4-15-16(23-7-22-15)6-14(12)26-20/h4-6,9-11,18-19H,3,7-8H2,1-2H3/t9-,10+,11+,18+,19+,20+/m1/s1 | | InChIKey | GMTJIWUFFXGFHH-WPAOEJHSSA-N | | SMILES | O=C(C=C1OCO2)[C@]3([H])C[C@@H](C)[C@H](C)[C@@]4([H])C5=CC6=C(OCO6)C=C5O[C@]12[C@]43[H] |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29329990 | | Storage Class | 11 - Combustible Solids |
| | SAUCHINONE Usage And Synthesis |
| Chemical Properties | Yellow crystalline powder, easily soluble in methanol and ethyl acetate, derived from Saururus chinensis. | | Uses | Sauchinone is a lignan first isolated from the aerial parts of S. chinensis, a plant used in Asian medicine for its anti-inflammatory, anti-angiogenic, and anti-nociceptive activities. Sauchinone has numerous effects on isolated cells, including blocking NF-κB activation in LPS-stimulated macrophages, inducing heme oxygenase-1 transcription in endothelial cells, and attenuating oxidative-stress-induced damage in myoblasts. Sauchinone is extensively metabolized in vivo, but intraperitoneal administration significantly reduces myocardial infarct size induced by ischemia/reperfusion in mice. | | Biological Activity | Sauchinone is an anti-inflammatory and antioxidant lignan isolated from Saururus chinensis a medical plant used for the treatment of fever, jaundice, oedema and inflammatory disease in oriental folk medicine. Sauchinone inhibits LPS-inducible iNOS (NOS II), TNF-α and COX-2 expression in macrophages through suppression of IKBα phosphorylation. It appears th at sauchinone protects against myocardial ischemia/reperfusion injury by inhibition of p28 phosphorylation. |
| | SAUCHINONE Preparation Products And Raw materials |
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