- Cephalomannine
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- $0.00 / 20mg
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2026-04-10
- CAS:71610-00-9
- Min. Order: 20mg
- Purity: 98% HPLC
- Supply Ability: 100kg
- Cephalomannine
-
- $60.00 / 1mL
-
2026-04-09
- CAS:71610-00-9
- Min. Order:
- Purity: 99.94%
- Supply Ability: 10g
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| | Cephalomannine Basic information |
| Product Name: | Cephalomannine | | Synonyms: | TAXOL B;BENZENEPROPANOICACID,ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-;BENZENEPROPANOIC ACID, ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OXET-9-YL ESTER,[2AR-[2A,4,4A,6,9[R*,S*(E)],11,12,12A,12B]]-;CEPHALOMANNINE;paclitaxel iMpurity I;CephaloMannine, froM Taxus chinensis;(αR,βS)-α-Hydroxy-β-[[(2E)-2-Methyl-1-oxo-2-buten-1-yl]aMino]benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-
12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;NSC 318735 | | CAS: | 71610-00-9 | | MF: | C45H53NO14 | | MW: | 831.9 | | EINECS: | | | Product Categories: | Inhibitors;Alkaloids;Antineoplastic and Immunosuppressive AntibioticsEnzyme Inhibitors by Enzyme;DNA polymerase - alphaAntibiotics;Antibiotics;Antibiotics A to;Antibiotics A-FAntibiotics;Antibiotics by Application;Chemical Structure Class;D to;Interferes with DNA SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Herb extract;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Impurities | | Mol File: | 71610-00-9.mol |  |
| | Cephalomannine Chemical Properties |
| Melting point | 139-141C | | Boiling point | 929.5±65.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO: 14 mg/mL, soluble | | pka | 11.95±0.20(Predicted) | | form | solid | | color | White to Pale Beige | | InChIKey | DBXFAPJCZABTDR-WBYYIXQISA-N | | CAS DataBase Reference | 71610-00-9 |
| Hazard Codes | Xi | | Risk Statements | 37/38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | HS Code | 29329990 |
| | Cephalomannine Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Occurrence | A taxane derivative, cephalomannine occurs in the extract of Cephalotaxus rnannii. It has
been obtained as colourless needles from MeOH aq. and is laevorotatory with a specific rotation of [α]D -41° (MeOH). | | Uses | Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most com | | Uses | Antitumor, antiproliferative. | | Uses | similar anti-cancer function as Taxol | | in vivo | Cephalomannine (0.4 mg/kg, intraperitoneal injection, 10 days) could significantly inhibit the growth of lung cancer cells in nude mice xenograft model, with no obvious side effects[3].
Cephalomannine can interrupt the interaction between APEX1 and HIF-1α by competitive binding with APEX1[3].
| Animal Model: | BALB/C nude mice xenograft model[3] | | Dosage: | 0.4 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Reduced the volume and weight of H460 xenograft tumors. |
| Animal Model: | BALB/c nude mice bone metastasis xenograft model[4] | | Dosage: | 10 mg/kg, 20 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Decreased bone destruction, reduced bioluminescence intensity and number of bone metastases, significantly extended time to endpoint events, decreased UBE2S expression and number of osteoclasts, and did not produce significant toxicity to the heart, liver, or kidney of nude mice. |
| | IC 50 | HIF-1α |
| | Cephalomannine Preparation Products And Raw materials |
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