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Cephalomannine

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Company Name: Nanjing Yuanzhi Biotechnology Co. Ltd.  Gold
Tel: 15805159960;
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Company Name: Shanghai Pureone Bio Technology, CO. LTD  Gold
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Company Name: Chembest Research Laboratories Limited  
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Company Name: Chemsky（shanghai）International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com

Cephalomannine manufacturers

  • Cephalomannine
  • Cephalomannine pictures
  • 2026-09-11
  • CAS:71610-00-9
  • Min. Order: 20mg
  • Purity: 98% HPLC
  • Supply Ability: 100kg
  • Cephalomannine
  • Cephalomannine pictures
  • $60.00
  • 2026-07-15
  • CAS:71610-00-9
  • Purity: 99.94%
  • Supply Ability: 10g
Cephalomannine Basic information
Product Name:Cephalomannine
Synonyms:TAXOL B;BENZENEPROPANOICACID,ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-;BENZENEPROPANOIC ACID, ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OXET-9-YL ESTER,[2AR-[2A,4,4A,6,9[R*,S*(E)],11,12,12A,12B]]-;CEPHALOMANNINE;CephaloMannine, froM Taxus chinensis;(αR,βS)-α-Hydroxy-β-[[(2E)-2-Methyl-1-oxo-2-buten-1-yl]aMino]benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)- 12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;NSC 318735;Paclitaxel EP Impurity B
CAS:71610-00-9
MF:C45H53NO14
MW:831.9
EINECS:
Product Categories:Inhibitors;Alkaloids;Antineoplastic and Immunosuppressive AntibioticsEnzyme Inhibitors by Enzyme;DNA polymerase - alphaAntibiotics;Antibiotics;Antibiotics A to;Antibiotics A-FAntibiotics;Antibiotics by Application;Chemical Structure Class;D to;Interferes with DNA SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Herb extract;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Impurities
Mol File:71610-00-9.mol
Cephalomannine Structure
Cephalomannine Chemical Properties
Melting point 139-141C
Boiling point 929.5±65.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO: 14 mg/mL, soluble
form solid
pka11.95±0.20(Predicted)
color White to Pale Beige
InChIKeyDBXFAPJCZABTDR-WBYYIXQISA-N
CAS DataBase Reference71610-00-9
Safety Information
Hazard Codes Xi
Risk Statements 37/38-41
Safety Statements 26-39
WGK Germany 3
HS Code 29329990
MSDS Information
ProviderLanguage
SigmaAldrich English
Cephalomannine Usage And Synthesis
Chemical PropertiesOff-White Solid
OccurrenceA taxane derivative, cephalomannine occurs in the extract of Cephalotaxus rnannii. It has been obtained as colourless needles from MeOH aq. and is laevorotatory with a specific rotation of [α]D -41° (MeOH).
UsesCephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most com
UsesAntitumor, antiproliferative.
Usessimilar anti-cancer function as Taxol
in vivo

Cephalomannine (0.4 mg/kg, intraperitoneal injection, 10 days) could significantly inhibit the growth of lung cancer cells in nude mice xenograft model, with no obvious side effects[3].
Cephalomannine can interrupt the interaction between APEX1 and HIF-1α by competitive binding with APEX1[3].

Animal Model:BALB/C nude mice xenograft model[3]
Dosage:0.4 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Reduced the volume and weight of H460 xenograft tumors.
Animal Model:BALB/c nude mice bone metastasis xenograft model[4]
Dosage:10 mg/kg, 20 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Decreased bone destruction, reduced bioluminescence intensity and number of bone metastases, significantly extended time to endpoint events, decreased UBE2S expression and number of osteoclasts, and did not produce significant toxicity to the heart, liver, or kidney of nude mice.
IC 50HIF-1α
Cephalomannine Preparation Products And Raw materials
Raw materialsTIGLOYL CHLORIDE
Tag:Cephalomannine(71610-00-9) Related Product Information
Homoharringtonine Baccatine III CEPHALOTAXINE 7-EPI-CEPHALOMANNINE (2R,3S)-3-Phenylisoserine ethylester 7-Epitaxol Paclitaxel IMpurity F N-Debenzoyl-N-[(3E)-hex-3-enoyl]paclitaxel Paclitaxel EP Impurity I ACETYLTAXOL, 7-(P) 7-EPI-10-DEACETYLTAXOL Deacetyltaxol Iso CephaloMannine Paclitaxel EP Impurity J Paclitaxel impurity 19/Taxol E/(αR,βS)-α-Hydroxy-β-[[(2S)-2-methyl-1-oxobutyl]amino]benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetr PACLITAXEL C Paclitaxel IMpurity O (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid