4-Amino-6-chloropyrimidin-5-ylamine

4-Amino-6-chloropyrimidin-5-ylamine Suppliers list

Company Name:	Shanghai Xiannuo Biotechnology Co., Ltd. Gold
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Company Name:	Yancheng KangdiSen Pharmaceutical Co., Ltd. Gold
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Company Name:	Nanbu County Chengxin Technology Co., Ltd.
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Company Name:	BeiJing Hwrk Chemicals Limted
Tel:	0757-86329057 18934348241
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4-Amino-6-chloropyrimidin-5-ylamine manufacturers

4-Amino-6-chloropyrimidin-5-ylamine Basic information

Product Name:	4-Amino-6-chloropyrimidin-5-ylamine
Synonyms:	4-CHLORO-5,6-DIAMINOPYRIMIDINE;5 6-DIAMINO-4-CHLOROPYRIMIDINE;4-Amino-6-chloropyrimidin-5-ylamine ,97%;6-Chloro-4,5-pyrimidinediamine;6-Chloro-4,5-diaminopyrimidine;4,5-Pyrimidinediamine, 6-chloro- (9CI);N-(1-phenylpropan-2-yl)-4,5-dihydrooxazol-2-amine;100063
CAS:	4316-98-7
MF:	C4H5ClN4
MW:	144.56
EINECS:	224-341-1
Product Categories:	Heterocycle-Pyrimidine series;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;PYRIMIDINE
Mol File:	4316-98-7.mol

4-Amino-6-chloropyrimidin-5-ylamine Chemical Properties

Melting point	252 °C (decomp)
Boiling point	336.7±37.0 °C(Predicted)
density	1.565
Fp	157℃
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Sparingly), Methanol (Slightly)
form	powder to crystal
pka	2.39±0.10(Predicted)
color	White to Amber to Dark green
λmax	305nm(lit.)
Stability:	Hygroscopic
InChI	InChI=1S/C4H5ClN4/c5-3-2(6)4(7)9-1-8-3/h1H,6H2,(H2,7,8,9)
InChIKey	VNSFICAUILKARD-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=C(N)C(N)=N1
CAS DataBase Reference	4316-98-7
EPA Substance Registry System	4,5-Pyrimidinediamine, 6-chloro- (4316-98-7)

Safety Information

MSDS Information

4-Amino-6-chloropyrimidin-5-ylamine Usage And Synthesis

Chemical Properties	Light yellow solid
Uses	4-Amino-6-chloropyrimidin-5-ylamine is a chlorinated diaminopyrimidine used in the preparation of various bioactive choloropurine derivatives.
Synthesis	5413-85-4 4316-98-7 Step 1: 4,6-Dichloropyrimidin-5-amine (1.64 g, 10 mmol) was suspended in 5 mL of concentrated hydrochloric acid. The suspension was transferred to a sealed tube, ammonia solution was added and the reaction was stirred at 100 °C overnight. Upon completion of the reaction, the solid product was collected by filtration and dried under vacuum to afford the target compound 6-chloropyrimidine-4,5-diamine as a yellow solid (1.2 g, 83% yield).LC-MS analysis showed m/z 145 ([M+H]+).
References	[1] Patent: WO2006/46023, 2006, A1. Location in patent: Page/Page column 115-116 [2] Patent: WO2008/75110, 2008, A1. Location in patent: Page/Page column 116 [3] Patent: WO2007/125315, 2007, A2. Location in patent: Page/Page column 115 [4] Patent: WO2007/125325, 2007, A1. Location in patent: Page/Page column 92-93 [5] Organic Process Research and Development, 2011, vol. 15, # 4, p. 841 - 854

4-Amino-6-chloropyrimidin-5-ylamine Preparation Products And Raw materials

Raw materials	Phosphorus oxitrichloride-->Ammonium hydroxide-->Trifluoroacetic acid-->Nickel-->N,N-Diisopropylethylamine-->4,6-Dihydroxypyrimidine-->4,5-Diamino-6-hydroxypyrimidine-->5-Amino-4,6-dichloropyrimidine
Preparation Products	6,7-dimethyl-1H-pteridin-4-one-->4-Chloro-pteridine

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