| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
- Z-VAL-OSU
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- $1.00
-
2019-07-06
- CAS:3496-11-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1ton
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| | Z-VAL-OSU Basic information |
| Product Name: | Z-VAL-OSU | | Synonyms: | Z-VALINE-OSU;Z-VAL-OSU;Z-L-VALINE HYDROXYSUCCINIMIDE ESTER;Z-L-VALINE N-HYDROXYSUCCINIMIDE ESTER;2,5-dioxopyrrolidin-1-yl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate;phenyl N-[(3S)-1-(2,5-dioxopyrrolidin-1-yl)-4-methyl-2-oxopentan-3-yl]carbamate;(2,5-dioxopyrrolidin-1-yl) (2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoate;N-CARBOBENZOXY-L-VALINE-N-HYDROXYSUCCINIMIDE ESTER | | CAS: | 3496-11-5 | | MF: | C17H20N2O6 | | MW: | 348.35 | | EINECS: | 222-493-3 | | Product Categories: | Z-Amino Acids and Derivatives;Z-Amino acid series;Amino Acid Derivatives | | Mol File: | 3496-11-5.mol |  |
| | Z-VAL-OSU Chemical Properties |
| Melting point | 114-118℃ | | density | 1.30±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Soluble in 1mmol in 2mL DCM. | | pka | 10.51±0.46(Predicted) | | form | Powder | | color | White to off-white | | Optical Rotation | -21.534°(C=0.01 g/ml Dioxane) | | CAS DataBase Reference | 3496-11-5 |
| | Z-VAL-OSU Usage And Synthesis |
| Chemical Properties | White to off- white powder | | Uses | N-Benzyloxycarbonyl-L-valine N-succinimidyl ester, is an amino acid which is widely used in pharmaceutical and food industry. | | Synthesis | Step 1. To a stirred solution of N-hydroxybutanediimide (1 g, 4 mmol) and CBZ-L-valine (459 mg, 4 mmol) in tetrahydrofuran (THF, 20 mL) was added N,N'-dicyclohexylcarbodiimide (DCC, 908 mg, 4.4 mmol) at 0° C. The reaction was carried out at room temperature. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated to afford (S)-2,5-dioxopyrrolidin-1-yl 2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate (yield: 90%). | | References | [1] Chemical Communications, 2015, vol. 51, # 67, p. 13213 - 13216
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 28, p. 7736 - 7749
[3] Patent: WO2015/95227, 2015, A2. Location in patent: Page/Page column 133
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 989 - 1000
[5] Journal of the American Chemical Society, 2003, vol. 125, # 22, p. 6677 - 6686 |
| | Z-VAL-OSU Preparation Products And Raw materials |
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