- 2,3-Difluorobenzyl bromide
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- $100.00 / 1KG
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2025-09-25
- CAS:113211-94-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 2,3-Difluorobenzyl bromide Basic information |
| | 2,3-Difluorobenzyl bromide Chemical Properties |
| Boiling point | 190.5±25.0 °C(Predicted) | | density | 1.628 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.528(lit.) | | Fp | 194 °F | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | clear liquid | | color | Colorless to Light yellow | | Specific Gravity | 1.628 | | Sensitive | Lachrymatory | | BRN | 7089244 | | InChI | 1S/C7H5BrF2/c8-4-5-2-1-3-6(9)7(5)10/h1-3H,4H2 | | InChIKey | FTBSGSZZESQDBM-UHFFFAOYSA-N | | SMILES | Fc1cccc(CBr)c1F | | CAS DataBase Reference | 113211-94-2(CAS DataBase Reference) | | NIST Chemistry Reference | 2,3-Difluorobenzyl bromide(113211-94-2) |
| Hazard Codes | C,Xi | | Risk Statements | 34-36/37/38 | | Safety Statements | 26-36/37/39-45-25-36/37 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | F | 10-19-21 | | Hazard Note | Corrosive/Lachrymatory | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29049090 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Skin Corr. 1B |
| | 2,3-Difluorobenzyl bromide Usage And Synthesis |
| Chemical Properties | clear colorless to light yellow liquid | | Uses | 2,3-Difluorobenzyl bromide was used in the synthesis of chemokine antagonists. | | Synthesis | Step 2 (MW-S2): phosphorus tribromide (6.7 mL, 69.44 mmol) was added dropwise to a solution of diethyl ether (250 mL) of 2,3-difluorobenzyl alcohol (20 g, 138.88 mmol) at -10 °C. The reaction mixture was stirred at -10 °C for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution. The organic layer was separated and the aqueous layer was extracted with diethyl ether (2 x 100 mL). The combined organic layers were washed sequentially with water (100 mL), brine (100 mL), dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to give 20 g of 2,3-difluorobenzyl bromide (MW-52) as a light brown liquid, which can be used in the next reaction without further purification. | | References | [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 5, p. 1005 - 1009
[2] Patent: WO2014/140279, 2014, A1. Location in patent: Page/Page column 88; 170 |
| | 2,3-Difluorobenzyl bromide Preparation Products And Raw materials |
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