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- 4-AMINO-PYRIDIN-2-OL
-
- $1.10
-
2026-08-20
- CAS:38767-72-5
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 4-AMINO-PYRIDIN-2-OL
-
- $10.00
-
2026-03-20
- CAS:38767-72-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
|
| | 4-Amino-pyridin-2-ol Basic information |
| | 4-Amino-pyridin-2-ol Chemical Properties |
| Melting point | 219-221 °C(Solv: acetone (67-64-1)) | | Boiling point | 310.7±35.0 °C(Predicted) | | density | 1.208±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | solid | | pka | 11.49±0.10(Predicted) | | Appearance | White to light brown Solid | | InChI | 1S/C5H6N2O/c6-4-1-2-7-5(8)3-4/h1-3H,(H3,6,7,8) | | InChIKey | SBQVQYPJWLJRQT-UHFFFAOYSA-N | | SMILES | Nc1ccnc(O)c1 | | CAS DataBase Reference | 38767-72-5 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | WGK 3 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 4-Amino-pyridin-2-ol Usage And Synthesis |
| Uses | 4-Amino-2-pyridone is used in the preparation of nucleoside analogues with antitumor and antiviral activity. | | Synthesis | General procedure for the synthesis of 4-aminopyridin-2-one from 2-chloro-4-aminopyridine: A mixture of 2-chloro-4-aminopyridine (127 mg, 1.0 mmol) and potassium hydroxide (280.6 mg, 5.0 mmol) in toluene (4.0 mL) was heated in a sealed tube and reacted for 72 hr at 170 °C. Upon completion of the reaction, the mixture was cooled to room temperature and the toluene solvent was subsequently removed by distillation under reduced pressure. The residue was purified by rapid chromatography on silica gel (eluent ratio dichloromethane/methanol/ammonia: 78/20/2) to afford the target product 4-aminopyridin-2-one (107 mg, 97% yield) as a light yellow solid. | | References | [1] Synlett, 2016, vol. 27, # 1, p. 67 - 69
[2] Tetrahedron, 1999, vol. 55, # 41, p. 11985 - 11996 |
| | 4-Amino-pyridin-2-ol Preparation Products And Raw materials |
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