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Chengdu Pukang Biotechnology Co., Ltd
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| Products Intro: |
Product Name:Fmoc-Lys (biotin-PEG4)-OH
CAS:1334172-64-3
Purity:95%,HPLC Package:10g/;50g/;500g/
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| | Fmoc-Lys (biotin-PEG4)-OH Basic information |
| Product Name: | Fmoc-Lys (biotin-PEG4)-OH | | Synonyms: | Fmoc-Lys (biotin-PEG4)-OH;12,15,18,21-Tetraoxa-2,8,24-triazanonacosanoic acid, 3-carboxy-29-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-9,25-dioxo-, 1-(9H-fluoren-9-ylmethyl) ester, (3S)-;Fmoc-Lys(dPEG(4)-Biotin)-OH;N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-[15-(biotinamido)-4,7,10,13-tetraoxa-pentadecanoyl]-L-lysine;Fmoc-N-Lys-(dPEG??-biotin)-OH-(acid) (QBD-10613) | | CAS: | 1334172-64-3 | | MF: | C42H59N5O11S | | MW: | 842.01 | | EINECS: | | | Product Categories: | | | Mol File: | 1334172-64-3.mol |  |
| | Fmoc-Lys (biotin-PEG4)-OH Chemical Properties |
| Boiling point | 1105.7±65.0 °C(Predicted) | | density | 1.236±0.06 g/cm3(Predicted) | | pka | 3.87±0.21(Predicted) |
| | Fmoc-Lys (biotin-PEG4)-OH Usage And Synthesis |
| Description | Fmoc-Lys (biotin-PEG4)-OH is a Lysine embedded biotin PEG linkers containing a carboxylic group and Fmoc-protected amine. Reaction of carboxylic with primary amino (-NH2) forms stable, irreversible amide bonds. The Fmoc group can be deprotected under basic condition to release the free amine which can be used for further conjugations. | | Uses | Fmoc-Lys (biotin-PEG4)-OH is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329 |
| | Fmoc-Lys (biotin-PEG4)-OH Preparation Products And Raw materials |
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