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6-Methoxy-1H-indole-3-carboxylic acid

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6-Methoxy-1H-indole-3-carboxylic acid manufacturers

6-Methoxy-1H-indole-3-carboxylic acid Basic information
Synthesis
Product Name:6-Methoxy-1H-indole-3-carboxylic acid
Synonyms:6-METHOXY-1H-INDOLE-3-CARBOXYLIC ACID;6-METHOXY-2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID;6-METHOXYINDOLE-3-CARBOXYLIC ACID;1H-Indole-3-carboxylicacid, 6-Methoxy-;6-Methoxy-3-indolecarboxylic Acid;Indole-3-carboxylic acid, 6-methoxy-;6-Methoxy-1H-indole-3-carboxylic acid, CAS 90924-43-9
CAS:90924-43-9
MF:C10H9NO3
MW:191.18
EINECS:
Product Categories:pharmacetical;Heterocycles series;Indoline & Oxindole
Mol File:90924-43-9.mol
6-Methoxy-1H-indole-3-carboxylic acid Structure
6-Methoxy-1H-indole-3-carboxylic acid Chemical Properties
Boiling point 447.6±25.0 °C(Predicted)
density 1.381±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka4.07±0.10(Predicted)
AppearanceLight brown to brown Solid
CAS DataBase Reference90924-43-9(CAS DataBase Reference)
Safety Information
HS Code 2933998090
MSDS Information
6-Methoxy-1H-indole-3-carboxylic acid Usage And Synthesis
SynthesisThere are two methods for synthesizing 6-Methoxy-1H-indole-3-carboxylic acid compounds. The first method involves preparing 6-methoxy-indole-3-carboxaldehyde from 6-methoxy-indole via a Vilsmeier-Hacck reaction, followed by oxidation of the aldehyde group with potassium permanganate to obtain 6-Methoxy-1H-indole-3-carboxylic acid. The second method involves hydrolyzing 6-methoxy-indole-3-carboxynitrile. This method mainly involves three steps: first, preparing 6-methoxy-indole-3-carboxaldehyde from 6-methoxy-indole via a Vilsmeier-Hacck reaction; then, reacting 6-methoxy-indole-3-carboxaldehyde with hydroxylamine hydrochloride in a one-step process to synthesize 6-methoxy-indole-3-carboxynitrile, which is then hydrolyzed to obtain 6-Methoxy-1H-indole-3-carboxylic acid. The synthetic reaction formula for 6-methoxy-3-indolecarboxylic acid is shown in the figure below:

Synthesis of 90924-43-9

Uses6-Methoxy-1H-indole-3-carboxylic acid is an indole organic compound and can be used as a pesticide and pharmaceutical intermediate.
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