|
|
| | Drofenine hydrochloride Basic information |
| Product Name: | Drofenine hydrochloride | | Synonyms: | LABOTEST-BB LT00244841;HEXAHYDROADIPHENINE HYDROCHLORIDE;hexahydroadiphenine;DROFENINE HCL;2-(diethylamino)ethylalpha-cyclohexylbenzeneacetate;2-diethylaminoethyl(alpha-phenylcyclohexane)acetatehydrochloride;adipheninehhydrochloride;alpha-cyclohexylbenzeneaceticacid2-(diethylamino)ethylesterhydrochloride | | CAS: | 548-66-3 | | MF: | C20H32ClNO2 | | MW: | 353.93 | | EINECS: | 208-954-1 | | Product Categories: | | | Mol File: | 548-66-3.mol |  |
| | Drofenine hydrochloride Chemical Properties |
| Melting point | 145-147° | | storage temp. | 2-8°C | | solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly) | | form | Solid | | color | White to Off-White |
| WGK Germany | 2 | | RTECS | GU6825000 | | Toxicity | LD50 i.v. in mice: 65.6 mg/kg (Fleisch) |
| | Drofenine hydrochloride Usage And Synthesis |
| Originator | Trasentine A,Ciba | | Uses | Spasmolytic | | Uses | Drofenine is a widely used anticholinergic drug. It acts on smooth muscle to stop muscle spasms. | | Manufacturing Process | 17.4 parts of diphenylacetic acid 2-(diethylamino)ethyl ester were solved in
200 parts of acetic acid and hydrogenated over platinum catalyst. After the
calculated volume of hydrogen was passed, the catalyst was filtered off and
the solvent was removed to dryness. Ether, water and a potassium carbonate
solution were added to the remaining oil and were thoroughly shaken. The
ether layer was washed with water and dried over potassium carbonate. The
solvent was removed, the remaining oil was distilled in vacuum to give 2-
(diethylamino)ethyl α-phenylcyclohexaneacetate; BP 150°-160°C/0.2 mm Hg.
In practice it is usually used as hydrochloride. | | Therapeutic Function | Spasmolytic | | IC 50 | BChE |
| | Drofenine hydrochloride Preparation Products And Raw materials |
|