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| | METHYL 6-AMINOCAPROATE HYDROCHLORIDE Basic information |
| Product Name: | METHYL 6-AMINOCAPROATE HYDROCHLORIDE | | Synonyms: | METHYL 6-AMINOHEXANOATE HYDROCHLORIDE;METHYL 6-AMINOCAPROATE HYDROCHLORIDE;TIMTEC-BB SBB003739;Methyl 6-aminohexanoate hydrochloride,Methyl 6-aminocaproate hydrochloride;6-Aminocaproic acid methyl ester hydrochloride;6-Aminohexanoic acid methyl ester hydrochloride;6-Aminohexanoic acid methyl ester monohydrochloride;Methyl 6-aMinocapte hydrochloride | | CAS: | 1926-80-3 | | MF: | C7H16ClNO2 | | MW: | 181.66 | | EINECS: | | | Product Categories: | | | Mol File: | 1926-80-3.mol |  |
| | METHYL 6-AMINOCAPROATE HYDROCHLORIDE Chemical Properties |
| Melting point | 117-124 °C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | BRN | 3687692 | | Major Application | peptide synthesis | | InChI | 1S/C7H15NO2.ClH/c1-10-7(9)5-3-2-4-6-8;/h2-6,8H2,1H3;1H | | InChIKey | YSLDOTFAFZJPOC-UHFFFAOYSA-N | | SMILES | Cl.COC(=O)CCCCCN |
| Hazard Codes | Xn | | Risk Statements | 22-36 | | Safety Statements | 26 | | WGK Germany | 3 | | F | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 |
| | METHYL 6-AMINOCAPROATE HYDROCHLORIDE Usage And Synthesis |
| Uses | Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | Thionyl chloride (1.4 eq.) was slowly added dropwise to a methanolic suspension of 6-aminohexanoic acid (1 eq.) at 0 °C while maintaining stirring. The reaction mixture was continued to be stirred overnight at room temperature. Subsequently, the solvent and unreacted thionyl chloride were removed by distillation under reduced pressure to give methyl 6-aminohexanoate hydrochloride. | | References | [1] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4737 - 4740
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 16, p. 6516 - 6532
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 20, p. 6094 - 6103
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 16, p. 5950 - 5961
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3591 - 3594 |
| | METHYL 6-AMINOCAPROATE HYDROCHLORIDE Preparation Products And Raw materials |
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