|
|
| | 2,2-Dimethoxypropane Basic information |
| | 2,2-Dimethoxypropane Chemical Properties |
| Melting point | -47 °C | | Boiling point | 83 °C (lit.) | | density | 0.847 g/mL at 25 °C (lit.) | | vapor density | 3.59 (vs air) | | vapor pressure | 60 mm Hg ( 15.8 °C) | | refractive index | n20/D 1.378(lit.) | | Fp | 12 °F | | storage temp. | Store below +30°C. | | solubility | 180g/l | | form | Liquid | | Specific Gravity | 0.852 (20/4℃) | | color | Clear colorless | | explosive limit | 31%, 58°F | | Water Solubility | 18 g/100 mL (25 ºC) | | BRN | 635678 | | Henry's Law Constant | 1.4×10-1 mol/(m3Pa) at 25℃, Ebert et al. (2023) | | Stability: | Stable. Highly flammable - note low flash point. Vapour may form an explosive mixture with air. May form explosive peroxides when exposed to air. Incompatible with strong oxidizing agents. | | InChI | 1S/C5H12O2/c1-5(2,6-3)7-4/h1-4H3 | | InChIKey | HEWZVZIVELJPQZ-UHFFFAOYSA-N | | SMILES | COC(C)(C)OC | | Surface tension | 21.46mN/m at 298.15K | | CAS DataBase Reference | 77-76-9(CAS DataBase Reference) | | NIST Chemistry Reference | 2,2-Dimethoxypropane(77-76-9) | | EPA Substance Registry System | Propane, 2,2-dimethoxy- (77-76-9) |
| Hazard Codes | F,Xi | | Risk Statements | 11-36-36/37/38 | | Safety Statements | 26-9-37/39-33-16-33,37/39 | | RIDADR | UN 1993 3/PG 2 | | WGK Germany | 2 | | F | 10-21 | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29110000 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 2 | | Toxicity | LD50 orally in Rabbit: > 2260 mg/kg LD50 dermal Rat > 2100 mg/kg |
| | 2,2-Dimethoxypropane Usage And Synthesis |
| Chemical Properties | colourless liquid; B.P. 83℃. Ethereal odor. Soluble in alcohol, miscible with ess, oils
and perfume chemicals. Stable when pure and at room temp.
Decomposes into Acetone and Methanol
during heating in presence of moisture or
traces of mineral acid. Presumably not used in flavors.
Rarely used in perfumes - for ethereal top-notes and "alcohol-like" effects. Produced synthetically via orthoformic ester
or vinyl ether. Also from formiminomethyl-ether hydrochloride. | | Uses | 2,2-Dimethoxypropane(DMP) is used in histology and considered to be more efficient than ethanol for the dehydration of animal tissue. | | Uses | 2,2-Dimethoxypropane acts as a dehydrating agent. It also serves as an intermediate in the synthesis of vitamin E, vitamin A and various carotenoids such as astaxanthin. It is used as a reagent for the preparation of 1,2-diols, acetonides, isopropylidene derivatives of sugars, nucleosides, methyl esters of amino acids and enol ethers. | | General Description | 2,2-Dimethoxypropane is an organic compound, which may be used as a protecting agent in the process of the synthesis of structurally related alkaloids like narciclasine and lycoricidine using phenylbromide as the starting material. | | Toxics Screening Level | The ITSL for 2,2-Dimethoxypropane is being set at the default value of 0.1 μg/m3 with annual averaging under 232(1)(i). |
| | 2,2-Dimethoxypropane Preparation Products And Raw materials |
| Raw materials | 2,2-DIMETHYL-1,3-DIOXOLANE-->Trimethoxymethane-->Allyl phenyl ether-->Acetone-->Propyne | | Preparation Products | Doxifluridine-->SUCCINAMIC ACID-->L-Glutamic acid dimethyl ester hydrochloride-->[1,3]Dioxepino[5,6-c]pyridin-9-ol, 1,5-dihydro-3,3,8-trimethyl--->Propane, 2-methoxy-2-(1-methylethoxy)--->1-ETHOXY-1-METHOXYPROPANE-->trans-4-Hydroxy-L-proline methyl ester hydrochloride-->Tetramethyl orthosilicate-->1,3-Dioxan-5-ol, 2,2-dimethyl--->Methyl isopropyl ether-->Ethyl 3,4-O-isopropylideneshikiMate |
|