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- Boc-L-Chg-OH
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2026-09-11
- CAS:109183-71-3
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | Boc-L-Cyclohexylglycine Basic information | | Synthesis |
| Product Name: | Boc-L-Cyclohexylglycine | | Synonyms: | N-ALPHA-BUTOXYCARBONYL-L-CYCLOHEXYLGLYCINE;N-ALPHA-BUTOXYCARBONYL-L-CYCLOHEXYLGLYCINE HYDRATE;N-BOC-2-CYCLOHEXYL-L-GLYCINE;(S)-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXYL-ACETIC ACID;BOC-CHG-OH H2O;BOC-CYCLOHEXYL-GLYCINE;BOC-CYCLOHEXYL-GLY-OH;BOC-L-2-CYCLOHEXYLGLYCINE | | CAS: | 109183-71-3 | | MF: | C13H23NO4 | | MW: | 257.33 | | EINECS: | | | Product Categories: | | | Mol File: | 109183-71-3.mol |  |
| | Boc-L-Cyclohexylglycine Chemical Properties |
| Melting point | 83°C(lit.) | | Boiling point | 407.9±28.0 °C(Predicted) | | density | 1.111±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | pka | 4.01±0.10(Predicted) | | form | Liquid | | color | Clear colorless to pale yellow | | Optical Rotation | 11.8°(C=0.01g/mI, MEOH, 20°C, 589nm) | | Water Solubility | Slightly soluble in water. | | BRN | 5553687 | | Major Application | peptide synthesis | | InChI | InChI=1/C13H23NO4/c1-13(2,3)18-12(17)14-10(11(15)16)9-7-5-4-6-8-9/h9-10H,4-8H2,1-3H3,(H,14,17)(H,15,16)/t10-/s3 | | InChIKey | QSUXZIPXYDQFCX-JTQLQIEISA-N | | SMILES | C1(CCCCC1)[C@@H](C(=O)O)NC(=O)OC(C)(C)C |&1:6,r| | | CAS DataBase Reference | 109183-71-3(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29242990 | | Storage Class | 13 - Non Combustible Solids |
| | Boc-L-Cyclohexylglycine Usage And Synthesis |
| Synthesis | 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1-cyclohexyl-2-hydroxy-2-methylpropyl)-amide step 1 (S)-aminocyclohexylacetate hydrochloride (1.0 g, 5.16 mmol) was dissolved in 17 mL of 2:1,4-dioxane:water and cooled in an ice bath. Sodium hydroxide solution (10.4 mL of 1M aqueous solution) was slowly added to the reaction solution, followed by solid sodium bicarbonate (0.43 g, 5.16 mmol). Di-tert-butyl carbonate (1.68 g, 7.74 mmol) was added, and the reaction mixture was stirred for 16 h. The reaction mixture was partially evaporated, then absorbed in ethyl acetate and water, and acidified to pH 2 with potassium bisulfate solution. The layers were separated, and the aqueous layer was extracted twice with ethyl acetate. The combined ethyl acetate layer was washed with sodium chloride solution, dried over sodium sulfate, and evaporated to give 1.52 g of Boc-L-cyclohexylglycine.
 Figure: Synthetic Route of Boc-L-Cyclohexylglycine | | Chemical Properties | White powder | | Uses | N-Boc-2-cyclohexyl-L-glycine is used as pharmaceutical intermediate. | | Uses | N-Boc-L-cyclohexylglycine has been used as a reactant for the preparation of a potent hepatitis C protease inhibitor. | | reaction suitability | reaction type: Boc solid-phase peptide synthesis |
| | Boc-L-Cyclohexylglycine Preparation Products And Raw materials |
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