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| | 5-Bromo-2-pyridinecarboxylic Acid Basic information | | Uses |
| | 5-Bromo-2-pyridinecarboxylic Acid Chemical Properties |
| Melting point | 173-175°C | | Boiling point | 319.5±27.0 °C(Predicted) | | density | 1.813±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Soluble in methanol. | | form | Powder | | pka | 3.41±0.10(Predicted) | | color | White to off-white | | InChI | InChI=1S/C6H4BrNO2/c7-4-1-2-5(6(9)10)8-3-4/h1-3H,(H,9,10) | | InChIKey | MNNQIBXLAHVDDL-UHFFFAOYSA-N | | SMILES | C1(C(O)=O)=NC=C(Br)C=C1 | | CAS DataBase Reference | 30766-11-1(CAS DataBase Reference) |
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ALFA
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| | 5-Bromo-2-pyridinecarboxylic Acid Usage And Synthesis |
| Uses | 5-Bromopyridine-2-carboxylic acid is used as a pharmaceutical intermediate. Store in cool, dry place in a well sealed container. Store away from oxidizing agents.
| | Chemical Properties | white Cryst | | Uses | 5-Bromopyridine-2-carboxylic acid is used as a pharmaceutical intermediate. | | Synthesis | 4.1.7 Synthesis of 5-bromopyridine-2-carboxylic acid (11): In a 250 mL three-necked flask assembled with a stirrer, thermometer, and condenser tube, add 150 mL of water and 5-bromo-2-methylpyridine (10) (6.0 g, 35 mmol). After turning on the stirring and heating to 80 °C, potassium permanganate (KMnO4) (24.8 g, 157 mmol) was added in three batches at 1 h intervals. The reaction temperature was maintained at 80 °C and stirring was continued for 3-4 hours. Upon completion of the reaction, filtration was carried out to obtain a clarified filtrate. The pH of the filtrate was adjusted to 4-5 with concentrated hydrochloric acid, at which point a white solid precipitated. The filtrate was filtered to collect a small amount of product (11). The filtrate was concentrated under vacuum and an appropriate amount of ethanol was added to the residue to dissolve compound (11), at which time a large amount of white solid precipitated, the filtrate was again withdrawn and the solid discarded. Finally, the filtrate was concentrated under vacuum to give a light yellow solid product (11) (3.0 g, 39% yield). | | References | [1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3228 - 3236
[2] Journal fuer Praktische Chemie (Leipzig), 1932, vol. <2> 133, p. 36,49
[3] Heterocycles, 1981, vol. 15, # 1, p. 213 - 223
[4] Synthesis, 2003, # 4, p. 551 - 554
[5] Patent: US2005/113374, 2005, A1. Location in patent: Page/Page column 8 |
| | 5-Bromo-2-pyridinecarboxylic Acid Preparation Products And Raw materials |
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