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| | 5-Nitropyridine-2-carboxylic acid Basic information |
| | 5-Nitropyridine-2-carboxylic acid Chemical Properties |
| Melting point | 218-220°C | | Boiling point | 389.8±27.0 °C(Predicted) | | density | 1.570±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Soluble in dimethyl sulfoxide. | | form | Solid | | pka | 2.71±0.13(Predicted) | | color | Light Yellow | | InChI | InChI=1S/C6H4N2O4/c9-6(10)5-2-1-4(3-7-5)8(11)12/h1-3H,(H,9,10) | | InChIKey | QKYRCTVBMNXTBT-UHFFFAOYSA-N | | SMILES | C1(C(O)=O)=NC=C([N+]([O-])=O)C=C1 | | CAS DataBase Reference | 30651-24-2(CAS DataBase Reference) | | NIST Chemistry Reference | Picolinic acid, 5-nitro-(30651-24-2) |
| | 5-Nitropyridine-2-carboxylic acid Usage And Synthesis |
| Chemical Properties | Light Yellow Solid | | Uses | 5-Nitropyridine-2-carboxylic acid is a useful synthetic intermediate. | | Uses | It plays an important role in synthetic intermediate. | | Synthesis | General procedure for the synthesis of 5-nitro-2-pyridinecarboxylic acid from 2-bromo-5-nitropyridine: this method is based on the procedure reported by Oehlke, J.; Schroetter, E.; Dove, S.; Schick, H.; Niedrich, H. in Pharmazie 1983,38,591-596, with slight modifications. When N,N-dimethylformamide (DMF) was used instead of dimethylsulfoxide (DMSO) as solvent for the reaction with 2-bromo-5-nitropyridine and copper(I) cyanide, a subsequent hydrolysis step afforded the target product 5-nitro-2-pyridinecarboxylic acid in 70% yield. This product is usually used directly in subsequent reactions without further purification. | | References | [1] Patent: WO2004/14904, 2004, A1. Location in patent: Page 53
[2] Pharmazie, 1983, vol. 38, # 9, p. 591 - 596
[3] Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1951, vol. 288, p. 237,241
[4] Patent: WO2009/141386, 2009, A1. Location in patent: Page/Page column 89 |
| | 5-Nitropyridine-2-carboxylic acid Preparation Products And Raw materials |
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