- Difluoroacetic acid
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- $90.00
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2026-08-25
- CAS:381-73-7
- Min. Order: 10kg
- Purity: 0.99
- Supply Ability: 20tons
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| | Difluoroacetic acid Basic information |
| | Difluoroacetic acid Chemical Properties |
| Melting point | -1 °C (lit.) | | Boiling point | 132-134 °C (lit.) | | density | 1.526 g/mL at 25 °C (lit.) | | vapor pressure | 11.7hPa at 25℃ | | refractive index | n20/D 1.344(lit.) | | Fp | 174 °F | | storage temp. | 2-8°C | | solubility | 540.54g/L in organic solvents at 20 ℃ | | form | Liquid | | pka | pK1:1.33 (25°C) | | color | Clear colorless to light brown | | Specific Gravity | 1.527 (20℃) | | Water Solubility | 1000g/L at 37℃ | | BRN | 1098588 | | Henry's Law Constant | 3.0×102 mol/(m3Pa) at 25℃, Burkholder et al. (2019) | | InChI | 1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6) | | InChIKey | PBWZKZYHONABLN-UHFFFAOYSA-N | | SMILES | OC(=O)C(F)F | | LogP | 0.601 at 37℃ | | CAS DataBase Reference | 381-73-7(CAS DataBase Reference) | | NIST Chemistry Reference | Difluoroacetic acid(381-73-7) | | EPA Substance Registry System | Acetic acid, difluoro- (381-73-7) |
| Hazard Codes | C | | Risk Statements | 34-35 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 3 | | RTECS | AG9900000 | | Hazard Note | Corrosive | | TSCA | TSCA listed | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29159080 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Acute Tox. 4 Inhalation
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1A |
| | Difluoroacetic acid Usage And Synthesis |
| Chemical Properties | clear colorless to light brown liquid | | Uses | Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine. | | Definition | ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines. | | Flammability and Explosibility | Non flammable | | Synthesis | The following is the generic synthesis procedure employed in Examples 10 to 12: 2 g of dichloroacetic acid was added to an aqueous solution of potassium fluoride (KF) preheated to 120°C. The reaction system was kept continuously stirred at 120°C for 1 hour. Upon completion of the reaction, the system was cooled to room temperature and the aqueous solution was subsequently analyzed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR) and nuclear magnetic resonance fluorine spectroscopy (19F NMR). The specific operating conditions and corresponding results are detailed in the following table (III). | | Purification Methods | Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.] | | References | [1] Patent: US2013/131375, 2013, A1. Location in patent: Paragraph 0116; 0117; 0118; 0119 |
| | Difluoroacetic acid Preparation Products And Raw materials |
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