- BIBF 1202
-
- $64.00
-
2026-07-27
- CAS:894783-71-2
- Purity: 98.69%
- Supply Ability: 10g
|
| | BIBF 1202 Basic information |
| Product Name: | BIBF 1202 | | Synonyms: | (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1
-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylic acid;Nintedanib impurity A;Intedanib Impurity A;Nintedanib Carboxylic Acid;Nintedanib-010;BIBF 1202;(3Z)-2,3-Dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid;Nintedanib-1 | | CAS: | 894783-71-2 | | MF: | C30H31N5O4 | | MW: | 525.6 | | EINECS: | | | Product Categories: | | | Mol File: | 894783-71-2.mol |  |
| | BIBF 1202 Chemical Properties |
| Melting point | >216°C (dec.) | | Boiling point | 759.5±60.0 °C(Predicted) | | density | 1.331±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Aqueous Base (Slightly, Heated) | | pka | 3.94±0.20(Predicted) | | form | Solid | | color | Light Yellow to Yellow |
| | BIBF 1202 Usage And Synthesis |
| Description | BIBF 1202 is an active metabolite of the VEGFR, FGFR, and PDGFR inhibitor BIBF 1120 (nintedanib; ). It is formed from BIBF 1120 by intracellular esterases. BIBF 1202 inhibits VEGFR2 with an IC50 value of 62 nM. | | Uses | Nintedanib Carboxylic Acid is a related compound of Intedanib (I666650), an indolinone derivative that inhibits angiokinase and an antitumor agent. | | References | [1] FRANK HILBERG. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy.[J]. Cancer research, 2008, 68 12: 4774-4782. DOI: 10.1158/0008-5472.can-07-6307
[2] DAN LIN . Simultaneous determination of nintedanib and its metabolite by UPLC–MS/MS in rat plasma and its application to a pharmacokinetic study[J]. Journal of pharmaceutical and biomedical analysis, 2016, 117: Pages 173-177. DOI: 10.1016/j.jpba.2015.08.024 |
| | BIBF 1202 Preparation Products And Raw materials |
|