(Fmoc-Cys-OH)2

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(Fmoc-Cys-OH)2 manufacturers

  • (Fmoc-Cys-OH)2
  • (Fmoc-Cys-OH)2 pictures
  • 2026-09-15
  • CAS:135273-01-7
  • Min. Order: 1kg
  • Purity: 98%
  • Supply Ability: 1T
(Fmoc-Cys-OH)2 Basic information
Product Name:(Fmoc-Cys-OH)2
Synonyms:(FMOC-CYS)2;N-ALPHA,N-ALPHA-BIS-FMOC-L-CYSTINE;N,N'-DI-9-FLUORENYLMETHOXYCARBONYL-L-CYSTINE;(Fmoc-Cys-OH)2 (Disulfide bond);Nα,Nα-Bis-FMoc-L-cystine;N,N'-Bis-FMoc-L-cystine;Nalpha,Nalpha-Bis-Fmoc-L-cystine(Disulfide bond);(Fmoc-L-Cys-OH)2
CAS:135273-01-7
MF:C36H32N2O8S2
MW:684.78
EINECS:
Product Categories:
Mol File:135273-01-7.mol
(Fmoc-Cys-OH)2 Structure
(Fmoc-Cys-OH)2 Chemical Properties
Melting point 189-201 °C
Boiling point 925.8±65.0 °C(Predicted)
density 1.412
Fp 513.7℃
storage temp. Sealed in dry,2-8°C
pka3.06±0.10(Predicted)
Safety Information
Safety Statements 24/25
HS Code 29309090
MSDS Information
(Fmoc-Cys-OH)2 Usage And Synthesis
Chemical PropertiesWhite to off-white powder
Synthesis
L-Cystine

56-89-3

9-Fluorenylmethyl chloroformate

28920-43-6

(FMOC-CYS-OH)2

135273-01-7

The general procedure for the synthesis of Fmoc-L-cystine from L-cystine and 9-fluorenylmethyl chloroformate was as follows: sodium carbonate (4.6 g, 43.6 mmol) and L-cystine (5.0 g, 20.8 mmol) were dissolved in deionized water (200 mL). The reaction system was cooled to 10 °C. Methyl 9-fluorenyl chloroformate (Fmoc-Cl, 11.85 g, 45.8 mmol) was dissolved in 1,4-dioxane (80 mL) and this solution was slowly added dropwise to the above aqueous L-cystine solution. The reaction mixture was stirred continuously at 10 °C for 2 h, followed by natural warming to room temperature. Upon completion of the reaction, a thick white precipitate was produced, which was drained through a sintered glass funnel. The resulting solid was washed with ether (50 mL) and ground, followed by drying under vacuum for 48 hours. The final N,N'-bis(Fmoc)-L-cystine (14.0 g, 98% yield) was obtained as a white powdery product.

References[1] Patent: US2007/37963, 2007, A1. Location in patent: Page/Page column 11-12; Figure 4
(Fmoc-Cys-OH)2 Preparation Products And Raw materials
Raw materialsL-Cystine-->Fmoc-OSu-->9-Fluorenylmethyl chloroformate-->Water-->1,4-Dioxane-->Sodium carbonate
Preparation ProductsFmoc-Cys(tBu)-OH-->Fmoc-Cys(StBu)-OH
Tag:(Fmoc-Cys-OH)2(135273-01-7) Related Product Information
3,3'-Dithiodipropionic acid (Fmoc-Cys-OSu)2, (Disulfide bond) (Fmoc-Cys-OH)2 (Fmoc-Cys-OtBu)2, (disulfide bond) Fmoc-Lys-OH (Boc-Cys-OH)2