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ETOXAZOLE

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CAS:153233-91-1
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ETOXAZOLE Basic information
Product Name:ETOXAZOLE
Synonyms:ETOXAZOLE;Oxazole, 2-(2,6-difluorophenyl)-4-4-(1,1-dimethylethyl)-2-ethoxyphenyl-4,5-dihydro-;etoxazole (bsi, pa iso);yi-5301;2-(2,6-Difluorophenyl)-4-(4-(1,1-dimethylethyl)-2-ethoxyphenyl)-4,5-di hydrooxazole;ETOXAZOLE STANDARD;etoxazol;2-(2,6-Difluorophenyl)-4-...
CAS:153233-91-1
MF:C21H23F2NO2
MW:359.41
EINECS:201-167-4
Product Categories:
Mol File:153233-91-1.mol
ETOXAZOLE Structure
ETOXAZOLE Chemical Properties
Melting point 101-102°
Boiling point 449.1±45.0 °C(Predicted)
density 1.15±0.1 g/cm3(Predicted)
Fp 457℃
storage temp. Sealed in dry,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka2.04±0.70(Predicted)
form Solid
color White to Off-White
BRN 8930214
Stability:Hygroscopic
Major Applicationagriculture
environmental
InChIInChI=1S/C21H23F2NO2/c1-5-25-18-11-13(21(2,3)4)9-10-14(18)17-12-26-20(24-17)19-15(22)7-6-8-16(19)23/h6-11,17H,5,12H2,1-4H3
InChIKeyIXSZQYVWNJNRAL-UHFFFAOYSA-N
SMILESO1CC(C2=CC=C(C(C)(C)C)C=C2OCC)N=C1C1=C(F)C=CC=C1F
EPA Substance Registry SystemEtoxazole (153233-91-1)
Safety Information
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
RTECS RP6795100
Storage Class11 - Combustible Solids
Hazard ClassificationsAquatic Acute 1
Aquatic Chronic 1
Hazardous Substances Data153233-91-1(Hazardous Substances Data)
ToxicityLD50 in rats (mg/kg): >5000 orally; >2000 dermally; LC50 (96 hr) in Japanese carp: 0.89 mg/l (Ishida)
MSDS Information
ETOXAZOLE Usage And Synthesis
DescriptionEtoxazole is an organofluorine acaricide. It induces toxicity in two-spotted spider mite (T. urticae) larvae (LC50 = 0.036 mg/L for the London reference strain) through inhibition of chitin synthase 1. It reduces acetylcholinesterase (AChE) activity in the freshwater fish O. niloticus in a concentration-dependent manner. Etoxazole (2.2-22 mg/kg per day) inhibits the activity of catalase, glutathione peroxidase (GPX), and AChE in the liver and kidneys of rats in a dose-dependent manner. Formulations containing etoxazole have been used for the control of mites in agriculture.
Chemical PropertiesPale-yellow liquid when pure or reddish-brown liquid or semisolid as a technical product. Mild odor.
UsesAcaricide.
UsesIsotope labelled Etoxazole is a acaricide/insecticide that works via chitin biosynthesis inhibition for the control of mites. Used as a standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698235).
DefinitionChEBI: Etoxazole is an organofluorine acaricide.
Potential ExposureAromatic hydrocarbon; Thiazole fungicide Etridiazole is a fungicide used in some countries as a seed treatment on barley, beans, corn, cotton, peanuts, peas, sorghum, soybeans, safflower, and wheat. It is also used on cotton for in-furrow application at planting, on ornamental plants and shrubs by horticultural nurseries, on nonbearing citrus and nonbearing coffee, and for golf course fairways, tees and greens. Some states hold Special Local Need registrations for use on tobacco transplants
ShippingUN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. Military driver shall be given full and complete information regarding shipment and conditions in case of emergency. AR 50-6 deals specifically with the shipment of chemical agents. Shipments of agent will be escorted in accordance with AR 740-32.
IncompatibilitiesDiazo compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. This chemical is sensitive to prolonged exposure to heat. This chemical is incompatible with strong oxidizing agents
Waste DisposalIncineration would be an effective disposal procedure where permitted. If an efficient incinerator is not available, the product should be mixed with large amounts of combustible material and contact with the smoke should be avoided. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers
References[1] PETER DEMAEGHT . High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticae[J]. Insect Biochemistry and Molecular Biology, 2014, 51: Pages 52-61. DOI: 10.1016/j.ibmb.2014.05.004
[2] MEHMET YILMAZ  Mustafa C  Eyyup Rencuzogullari. Investigations on the effects of etoxazole in the liver and kidney of Wistar rats[J]. Environmental Science and Pollution Research, 2017, 24 24: 19635-19639. DOI: 10.1007/s11356-017-9601-5
[3] YUSUF SEVGILER  Nevin ü  Elif zcan Oru. Evaluation of etoxazole toxicity in the liver of Oreochromis niloticus[J]. Pesticide Biochemistry and Physiology, 2004, 78 1: Pages 1-8. DOI: 10.1016/j.pestbp.2003.09.004
ETOXAZOLE Preparation Products And Raw materials
Raw materials2,6-Difluorobenzamide-->Chloroacetaldehyde dimethyl acetal-->1-tert-butyl-3-ethoxybenzene
Tag:ETOXAZOLE(153233-91-1) Related Product Information
Ethanethiol FLUACRYPYRIM Fenpyroximate Tebufenpyrad Fenbutatin oxide Bromopropylate FLUFENZINE Propargite ACEQUINOCYL Fenazaquin Clofentezine Azocyclotin Benzoximate 1,1'-Thiobisethane ETOXAZOLE etoxazole100ug/ml 2-FLUORO-BENZIMIDIC ACID ETHYL ESTER ETOXAZOLE SOLUTION 100UG/ML IN TOLUENE 1ML

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