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- 4-NO2-Phe-Oet.HCl
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2026-09-11
- CAS:58816-66-3
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | H-4-NITRO-PHE-OET HCL Basic information |
| Product Name: | H-4-NITRO-PHE-OET HCL | | Synonyms: | P-NITRO-L-PHENYLALANINE ETHYL ESTER HYDROCHLORIDE;ETHYL (S)-2-AMINO-3-(4-NITROPHENYL)PROPANOIATE;H-PHE(4-NO2)-OET HCL;H-4-NITRO-PHE-OET HCL;4-NITRO-L-PHENYLALANINE ETHYL ESTER HYDROCHLORIDE;ethyl 4-nitro-3-phenyl-L-alaninate monohydrochloride;3-(4-NITRO-PHENYL)-L-ALANINE ETHYL ESTER HCL;p-Nitrophenylalanine ethyl ester hydrochloride | | CAS: | 58816-66-3 | | MF: | C11H15ClN2O4 | | MW: | 274.7 | | EINECS: | 261-455-0 | | Product Categories: | Phenylalanine [Phe, F] | | Mol File: | 58816-66-3.mol |  |
| | H-4-NITRO-PHE-OET HCL Chemical Properties |
| Melting point | 177-180 °C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL | | form | A crystalline solid | | color | White to off-white |
| | H-4-NITRO-PHE-OET HCL Usage And Synthesis |
| Uses | 3-(4-Nitro-phenyl)-L-alanine ethyl ester hydrochloride is an alanine derivative[1]. | | Synthesis | Thionyl chloride (21 mL, 0.29 mol) was slowly added dropwise to 500 mL of anhydrous ethanol at 0 °C and under nitrogen protection for a controlled time of 5 min. After the dropwise addition, the clarified reaction solution was continued to be stirred at 0 °C for 10 min, and then brought to room temperature and stirred for 30 min. A one-time addition of 4-nitro-L-phenylalanine (50.2 g, 0.24 mol) was added to the reaction system and the mixture was heated to reflux overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure to afford ethyl (S)-2-amino-3-(4-nitrophenyl)propionate hydrochloride (60 g, 92% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CD3OD): δ 8.21 (d, 2H), 7.54 (d, 2H), 4.39 (dd, 1H), 4.22 (q, 2H), 3.24-3.40 (m, 2H), 1.22 (t, 3H). | | References | [1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368 |
| | H-4-NITRO-PHE-OET HCL Preparation Products And Raw materials |
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