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3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione

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3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione Basic information
Product Name:3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione
Synonyms:3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione;CRBN ligand-148;2,6-Piperidinedione, 3-(4-bromo-2,6-dichlorophenyl)-
CAS:3036607-19-6
MF:C11H8BrCl2NO2
MW:337
EINECS:
Product Categories:
Mol File:3036607-19-6.mol
3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione Structure
3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione Chemical Properties
Boiling point 441.855±45.00 °C(Press: 760.00 Torr)(predicted)
density 1.687±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka10.706±0.40(predicted)
Safety Information
MSDS Information
3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione Usage And Synthesis
UsesCRBN ligand-148 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.
IC 50Cereblon
References[1] Mileti N, et al. Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chem Biol. 2025 Feb 21;20(2):507-521. DOI:10.1021/acschembio.4c00812
3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione Preparation Products And Raw materials
Tag:3-(4-Bromo-2,6-dichlorophenyl)piperidine-2,6-dione(3036607-19-6) Related Product Information
3-(4-bromo-2-chlorophenyl)piperidine-2,6-dione 2,6-Piperidinedione, 3-(3-bromo-2-chlorophenyl)- 3-(4-Bromophenyl)piperidine-2,6-dione 3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione 3-(4-Bromo-2-chloro-5-fluorophenyl)piperidine-2,6-dione 3-(4-Bromo-2-chloro-6-methylphenyl)piperidine-2,6-dione