| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
4-Iodo-2-nitroanisole manufacturers
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| | 4-Iodo-2-nitroanisole Basic information |
| | 4-Iodo-2-nitroanisole Chemical Properties |
| Melting point | 96-98°C | | Boiling point | 330.8±27.0 °C(Predicted) | | density | 1.893±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | Appearance | Light yellow to yellow Solid | | Sensitive | Light Sensitive |
| Provider | Language |
|
ALFA
| English |
| | 4-Iodo-2-nitroanisole Usage And Synthesis |
| Synthesis Reference(s) | Tetrahedron Letters, 10, p. 2427, 1969 DOI: 10.1017/S0009838800024678 | | Synthesis | General procedure for the synthesis of 4-iodo-2-nitroanisole from 2-nitroanisole: To a stirred solution of 2-nitroanisole (1 mmol) in dichloromethane (CH2Cl2) or 1,2-dichloroethane ((CH2Cl)2) (0.1 M) was added sequentially Ph3PAuNTf2 (0.025 mmol, 19 mg; if using the 2:1 complex of Ph3PAuNTf2 with toluene) and N-iodosuccinimide (NIS, 1.1 mmol, 248 mg). The reaction mixture was stirred at room temperature or reacted under reflux conditions until complete conversion of the feedstock was confirmed by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the solvent was evaporated under reduced pressure and the resulting crude product was purified by fast column chromatography using different ratios of hexane and ethyl acetate (EtOAc) as eluents, resulting in pure 4-iodo-2-nitroanisole. | | References | [1] Synlett, 2014, vol. 25, # 3, p. 399 - 402
[2] Journal of Organic Chemistry, 1990, vol. 55, # 11, p. 3552 - 3555
[3] Tetrahedron, 2004, vol. 60, # 41, p. 9113 - 9119
[4] Synthetic Communications, 2007, vol. 37, # 8, p. 1259 - 1265
[5] Synthesis, 2006, # 7, p. 1195 - 1199 |
| | 4-Iodo-2-nitroanisole Preparation Products And Raw materials |
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