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| | diMethyl lithosperMate B Basic information |
| Product Name: | diMethyl lithosperMate B | | Synonyms: | diMethyl lithosperMate B;Lithospermic acid B dimethyl ester;dmLSB;3-Benzofurancarboxylic acid, 2-(3,4-dihydroxyphenyl)-4-[(1E)-3-[(1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-methoxy-2-oxoethoxy]-3-oxo-1-propen-1-yl]-2,3-dihydro-7-hydroxy-, (1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-methoxy-2-oxoethyl ester, (2S,3S)-;(R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate;Dimethyl lithospermate B, 10 mM in DMSO | | CAS: | 875313-64-7 | | MF: | C38H34O16 | | MW: | 746.67 | | EINECS: | | | Product Categories: | Phenylpropanoids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 875313-64-7.mol |  |
| | diMethyl lithosperMate B Chemical Properties |
| Boiling point | 968.3±65.0 °C(Predicted) | | density | 1.525±0.06 g/cm3(Predicted) | | storage temp. | -20°C, protect from light | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | pka | 9.43±0.60(Predicted) | | color | White to off-white |
| | diMethyl lithosperMate B Usage And Synthesis |
| Chemical Properties | White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Salvia miltiorrhiza. | | Uses | Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP)[1][2]. | | target | Calcium Channel | Sodium Channel | Potassium Channel | | References | [1] Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113(11):1393-400. DOI:10.1161/CIRCULATIONAHA.105.601690
[2] Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143(6):765-73. DOI:10.1038/sj.bjp.0705969 |
| | diMethyl lithosperMate B Preparation Products And Raw materials |
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