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| | 2,5-Dichloro-3-nitropyridine Basic information |
| | 2,5-Dichloro-3-nitropyridine Chemical Properties |
| Melting point | 41-45 °C | | Boiling point | 265.3±35.0 °C(Predicted) | | density | 1.629±0.06 g/cm3(Predicted) | | Fp | >110°(230°F) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | pka | -4.99±0.10(Predicted) | | form | Crystalline Powder and/or Chunks | | color | Light beige-green to orange | | InChI | 1S/C5H2Cl2N2O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H | | InChIKey | OBUGJYJQJWMOQO-UHFFFAOYSA-N | | SMILES | [O-][N+](=O)c1cc(Cl)cnc1Cl | | CAS DataBase Reference | 21427-62-3(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi,T | | Risk Statements | 36/37/38-22-43-41-37/38-25 | | Safety Statements | 36/37/39-26-45 | | RIDADR | 2811 | | WGK Germany | 1 | | Hazard Note | Harmful | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 29333990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
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| | 2,5-Dichloro-3-nitropyridine Usage And Synthesis |
| Chemical Properties | Light yellow crystalline powder | | Uses | 2,5-Dichloro-3-Nitropyridine has useful herbicidal properties. Furthermore, it is useful as a chemical intermediate for dyes, pharmaceutical and other agricultural applications. | | Synthesis | (Step 1) 5-Chloro-3-nitropyridin-2-amine (10.0 g, 57.6 mmol) was dissolved in concentrated hydrochloric acid (100 mL), cooled to -10 °C and stirred continuously. An aqueous solution of sodium nitrite (9.94 g, 144 mmol) was slowly added dropwise (20 mL) over 30 min. After the dropwise addition, the reaction mixture was kept at 0 °C with continued stirring for 1 hour. Subsequently, the pH of the reaction solution was adjusted to 9 with 1N aqueous sodium hydroxide solution and then extracted with ethyl acetate. Insoluble impurities were removed by filtration and the organic layer was washed with saturated brine and dried with anhydrous magnesium sulfate. After filtration, the solvent was removed by distillation under reduced pressure to afford the target product 2,5-dichloro-3-nitropyridine (6.50 g, yield: 58.5%) as a solid.1H-NMR (CDCl3) δ: 8.60 (1H, d, J = 2.9 Hz), 8.24 (1H, d, J = 2.6 Hz). | | References | [1] Patent: WO2007/67875, 2007, A2. Location in patent: Page/Page column 15
[2] Patent: JP2016/56134, 2016, A. Location in patent: Paragraph 0165; 0166; 0167
[3] Patent: JP2016/56133, 2016, A. Location in patent: Paragraph 0158; 0159
[4] Patent: EP3109239, 2016, A1. Location in patent: Paragraph 0189
[5] Journal of the Chemical Society, 1952, p. 2042,2044 |
| | 2,5-Dichloro-3-nitropyridine Preparation Products And Raw materials |
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