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| | 4-Bromo-2-fluorobenzaldehyde Basic information |
| | 4-Bromo-2-fluorobenzaldehyde Chemical Properties |
| Melting point | 58-62 °C (lit.) | | Boiling point | 42°C 19mm | | density | 1.6698 (rough estimate) | | refractive index | 1.5700 (estimate) | | Fp | 42°C/19mm | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to crystal | | color | White to Orange to Green | | Water Solubility | INSOLUBLE | | Sensitive | Air Sensitive | | BRN | 7700208 | | InChI | InChI=1S/C7H4BrFO/c8-6-2-1-5(4-10)7(9)3-6/h1-4H | | InChIKey | UPCARQPLANFGQJ-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(Br)C=C1F | | CAS DataBase Reference | 57848-46-1(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Fluoro-4-bromobenzaldehyde(57848-46-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | IRRITANT, AIR SENSITIVE | | HS Code | 29130000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-Bromo-2-fluorobenzaldehyde Usage And Synthesis |
| Chemical Properties | lightyellowtobeigecrystal | | Uses | 4-Bromo-2-fluorobenzaldehyde is used in the synthesis of Nigeglanine hydrobromide. | | Uses | 4-Bromo-2-fluorobenzaldehyde is used in the preparation of nigeglanine hydrobromide. | | Uses | 4-Bromo-2-fluorobenzaldehyde has been used in the preparation of:
- 2-functionalized aromatic monoaldehydes, via reaction with different secondary amines and phenol
- fluorostilbenes
- benzyl amine-based histamine H3 antagonist having serotonin reuptake activity
- 6-bromo-2-(4-bromo-2-fluorophenyl)-2,3-dihydro-4H-chromen-4-one
| | Synthesis | General procedure for the synthesis of 4-bromo-2-fluorobenzaldehyde from 4-bromo-3-fluorobenzyl alcohol: To a solution of 4-bromo-3-fluorobenzyl alcohol (7.9 g, 38.5 mmol) in dichloromethane (160.0 mL) was added sodium acetate (940 mg, 11.5 mmol) and pyridinium chlorochromate (10.8 g, 50.0 mmol) sequentially. The reaction mixture was stirred at room temperature and protected from light for 2 hours. After completion of the reaction, the mixture was diluted with ethyl acetate (1.0 L) and filtered through a diatomaceous earth pad. The filtrate was washed sequentially with aqueous sodium bicarbonate (600 mL) and water (600 mL) and subsequently dried with anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, the resulting crude product was further purified by column chromatography to afford 4-bromo-2-fluorobenzaldehyde as a white solid (5.0 g, 63% yield). | | References | [1] Patent: WO2011/21209, 2011, A1. Location in patent: Page/Page column 38; 39
[2] Patent: US2012/101099, 2012, A1. Location in patent: Page/Page column 13; 14 |
| | 4-Bromo-2-fluorobenzaldehyde Preparation Products And Raw materials |
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