- Dehydro Nifedipine
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- $42.00 / 1mg
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2025-09-29
- CAS:67035-22-7
- Min. Order:
- Purity: 99.19%
- Supply Ability: 10g
- Oxidized Nifedipine
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- $0.10 / 1KG
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2019-12-29
- CAS:67035-22-7
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 1000 tons
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| | OXIDIZED NIFEDIPINE Basic information |
| Product Name: | OXIDIZED NIFEDIPINE | | Synonyms: | Nifedipine-1; Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined;Nifedipine Impurity Ⅰ:2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester;2,6-Dimethyl-4-(2′-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester, Oxidized Nifedipine;Divalproex Sodium Impurity 1;Nifedipine Nitrophenylpyridine Analog;dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate;Nifedipine impurity A (EP) | | CAS: | 67035-22-7 | | MF: | C17H16N2O6 | | MW: | 344.32 | | EINECS: | | | Product Categories: | Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals | | Mol File: | 67035-22-7.mol |  |
| | OXIDIZED NIFEDIPINE Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 41 | | Safety Statements | 26-39 | | WGK Germany | 2 |
| | OXIDIZED NIFEDIPINE Usage And Synthesis |
| Description | Dehydro nifedipine is an active metabolite of nifedipine , a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. | | Chemical Properties | Pale Yellow Solid | | Uses | Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons. | | Uses | The main Nifedipine metabolite in human plasma | | Definition | ChEBI: Dehydronifedipine is a phenylpyridine. | | Biochem/physiol Actions | CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent. | | References | [1] T. D. ARDIZZONE D D Xiao Hong Lu. Calcium-independent inhibition of glucose transport in PC-12 and L6 cells by calcium channel antagonists.[J]. American journal of physiology. Cell physiology, 2002, 27 1: C579-86. DOI: 10.1152/ajpcell.00451.2001
[2] KIRAN C PATKI D J G Lisa L Von Moltke. In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.[J]. Drug Metabolism and Disposition, 2003, 31 7: 938-944. DOI: 10.1124/dmd.31.7.938
[3] TETSURO AGO. Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload.[J]. Journal of Cardiovascular Translational Research, 2010, 3 4: 304-313. DOI: 10.1007/s12265-010-9182-x
[4] J. LEMAY. Regression of Neointimal Lesions in the Carotid Artery of Nifedipine-Treated SHR and WKY Rats: Possible Role of Apoptosis[J]. Journal of Vascular Research, 2001, 38 1: 462-470. DOI: 10.1159/000051079 |
| | OXIDIZED NIFEDIPINE Preparation Products And Raw materials |
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