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Sigma-Aldrich |
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021-61415566 800-8193336 |
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BOC Sciences |
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PROSTAGLANDIN A1 manufacturers
- Prostagladin E1
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-
2026-08-17
- CAS:14152-28-4
- Min. Order: 2Kg/Bag
- Purity: 99% up, High Density
- Supply Ability: 20 tons
- PROSTAGLANDIN A1
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- $1.00
-
2020-02-20
- CAS:14152-28-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200kgs
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| | PROSTAGLANDIN A1 Basic information |
| Product Name: | PROSTAGLANDIN A1 | | Synonyms: | prostaglandina(sup1);prostaglandine(sup1)-217;prostaglandina1syntheticcrystalline;(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1;(13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dienoate;C04685;ProstaglandinA1,(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1;Prostaglandin A1 (25 mg) | | CAS: | 14152-28-4 | | MF: | C20H32O4 | | MW: | 336.47 | | EINECS: | 682-017-9 | | Product Categories: | | | Mol File: | 14152-28-4.mol |  |
| | PROSTAGLANDIN A1 Chemical Properties |
| Melting point | 43°C | | Boiling point | 392.93°C (rough estimate) | | density | 1.0192 (rough estimate) | | refractive index | 1.4434 (estimate) | | storage temp. | -20°C | | solubility | acetone: 10 mg/mL, clear | | form | White solid. | | pka | 4.77±0.10(Predicted) | | color | Off-white | | biological source | synthetic | | BRN | 2003401 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. | | InChI | 1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1 | | InChIKey | BGKHCLZFGPIKKU-LDDQNKHRSA-N | | SMILES | O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | GY5977900 | | F | 8-10 | | HS Code | 2937500000 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 4 Oral
Repr. 1B |
| | PROSTAGLANDIN A1 Usage And Synthesis |
| Description | Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients. It also has growth-inhibitory activity on tumor cells; the IC50 value for the inhibition of human ovarian cancer is 7.5 μM. | | Uses | Prostaglandin A1 has been shown to inhibit human immunodeficiency virus type 1 (HIV-1) replication in various cell types. In addition, as a precursor to the anti-inflammatory prostaglandins, it activates pro-inflammatory PGD2 receptor CRTH2 initiating the anti-inflammatory response. | | Definition | ChEBI: Prostaglandin A1 is a prostaglandins A. It is a conjugate acid of a prostaglandin A1(1-). | | General Description | Prostaglandin A1(PGA1) belongs to the class of cyclopentenone prostaglandin. PGA1 is generated by the dehydration of prostaglandin E1 (PGE1). | | Biochem/physiol Actions | Prostaglandin A1 (PGA1) boosts the expression of human liver-specific cytochrome P450 4F3B (CYP4F3B) and stimulates the synthesis of 20-hydroxy-eicosatetraenoic acids (HETEs). It has an ability to stimulate cell differentiation, ferritin synthesis and heat shock response in human cells. PGA1 exhibits antitumor and antiviral activities. In addition, it also elicits anti-inflammatory effects by activating peroxisome proliferator-activated receptor (PPAR). Elevated levels of PGA1 has been observed in hypertension patients. | | Enzyme inhibitor | This eicosanoid (FWfree-acid = 336.47 g/mol; CAS 14152-28-4; Symbol: PGA1) induces apoptosis and stimulates the expression of stress genes. The structure and role of the prostaglandin A1 was investigated by Bergstrm and Samuelsson, who shared the 1982 Nobel Prize in Physiology or Medicine for their pioneering work on the eicosanoids. Target(s): CYP4F2; DNA topoisomerase II; HIV-1 transcription; 3ahydroxysteroid dehydrogenase, NADP+-dependent; IkB kinase; Mayaro virus replication; stress-induced NF-kB activation; and virus protein biosynthesis, or translation. | | References | [1] SANDRA J. LEE . Renal effects of prostaglandin A1 in patients with essential hypertension[J]. Kidney international, 1972, 1 4: Pages 254-262. DOI:10.1038/ki.1972.35
[2] MOKHTAR K. TOPPOZADA MD. Treatment of preeclampsia with prostaglandin A1[J]. American journal of obstetrics and gynecology, 1988, 159 1: Pages 160-165. DOI:10.1016/0002-9378(88)90514-5
[3] ANTONIO ROSSI. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase[J]. Nature, 2000, 403 6765: 103-108. DOI:10.1038/47520
[4] ASIM K MANDAL. Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation.[J]. Journal of immunology, 2005, 175 10: 6271-6273. DOI:10.4049/jimmunol.175.10.6271
[5] STEFANIA CARTA . Prostaglandin A1 inhibits avian influenza virus replication at a postentry level: Effect on virus protein synthesis and NF-κB activity[J]. Prostaglandins, leukotrienes, and essential fatty acids, 2014, 91 6: Pages 311-323. DOI:10.1016/j.plefa.2014.07.009
[6] ATSUKO TSUKIMOTO . A new role for PGA1 in inhibiting hepatitis C virus-IRES-mediated translation by targeting viral translation factors[J]. Antiviral research, 2015, 117: Pages 1-9. DOI:10.1016/j.antiviral.2015.01.013
[7] BEATRIZ DÍEZ-DACAL. Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity.[J]. Cancer research, 2011: 4161-4171. DOI:10.1158/0008-5472.can-10-3816
[8] B ANTA. PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes[J]. Cell Death & Disease, 2016, 7 7: e2311-e2311. DOI:10.1038/cddis.2016.219 |
| | PROSTAGLANDIN A1 Preparation Products And Raw materials |
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