- N4-Benzoylcytosine
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- $0.00 / 1Kg/Bag
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2026-01-30
- CAS:26661-13-2
- Min. Order: 1KG
- Purity: 99%min HPLC
- Supply Ability: 100kg
- N4-Benzoylcytosine
-
- $10.00 / 1KG
-
2026-01-30
- CAS:26661-13-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- N4-Benzoylcytosine
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- $0.00 / 5Kg
-
2026-01-29
- CAS:26661-13-2
- Min. Order: 1Kg
- Purity: 98%
- Supply Ability: 20Ton
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| | N4-Benzoylcytosine Basic information |
| | N4-Benzoylcytosine Chemical Properties |
| Melting point | >300 °C (dec.) (lit.) | | density | 1.33±0.1 g/cm3(Predicted) | | vapor pressure | 0Pa at 25℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Aqueous Acid (Slightly, Heated), DMSO+DCl (Slightly, Heated) | | form | Solid | | pka | 7.75±0.10(Predicted) | | color | Off-White | | InChI | InChI=1S/C11H9N3O2/c15-10(8-4-2-1-3-5-8)13-9-6-7-12-11(16)14-9/h1-7H,(H2,12,13,14,15,16) | | InChIKey | XBDUZBHKKUFFRH-UHFFFAOYSA-N | | SMILES | C(NC1=CC=NC(=O)N1)(=O)C1=CC=CC=C1 | | Surface tension | 72.2mN/m at 1g/L and 21.2℃ | | CAS DataBase Reference | 26661-13-2(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 20/22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 29335990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | N4-Benzoylcytosine Usage And Synthesis |
| Chemical Properties | White or almost white crystalline powder | | Uses | N4-Benzoylcytosine may be employed for the following syntheses:
- 3′-C-ethynyl and 3′-C-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides
- 2′-C-methyl-4′-thiocytidine, via the Pummerer reaction
- 2′-fluorinated L-nucleoside analogs
| | Uses | N4-Benzoylcytosine is a reactant in the synthesis of 1'',2''-cyclopentyl nucleosides as potential antiviral agents. | | General Description | N4-Benzoylcytosine is an amide and its anti-microbial activity against pathogenic microorganisms has been studied using the Disk Diffusion and the Pour Plate method. It can be synthesized via the condensation of benzoyl chloride with cytosine. | | Synthesis | Under nitrogen protection, 100 L of acetonitrile was added to the reactor as a solvent, followed by 22 kg (196 mol) of 6-aminopyrimidin-2(1H)-one (anhydrous cytosine), 25 g of 4-dimethylaminopyridine (DMAP), and 24 kg of triethylamine as a base. After cooling the reaction mixture to 5-8°C, 34 kg of benzoyl chloride was slowly added dropwise. After the dropwise addition, the reaction mixture was allowed to warm up naturally to room temperature and stirred at 25°C for 1 hour. Subsequently, the reaction mixture was slowly heated to 40-45°C and kept at this temperature for 2 hours. Upon completion of the reaction, it was cooled to room temperature and press-filtered. About 60 L of acetonitrile filtrate was collected for recycling, and the filter cake was washed sequentially with water and ethanol, and dried to give 40 kg of a white solid product, N4-benzoylcytosine, which was analyzed by liquid chromatography to be 99.2% pure. | | References | [1] Patent: US2011/245458, 2011, A1
[2] Chemical Communications, 2017, vol. 53, # 64, p. 8952 - 8955
[3] Heterocyclic Communications, 2007, vol. 13, # 4, p. 251 - 256
[4] Russian Journal of Organic Chemistry, 2008, vol. 44, # 3, p. 358 - 361
[5] Journal of the Chemical Society, 1956, p. 2388,2392 |
| | N4-Benzoylcytosine Preparation Products And Raw materials |
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