- Biotin-PEG2-COOH
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2025-06-07
- CAS:1365655-89-5
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Biotin-PEG2-Acid Basic information |
| Product Name: | Biotin-PEG2-Acid | | Synonyms: | Biotin-PEG2-Acid;(+)-Biotin-PEG2-CH2CH2COOH;Propanoic acid, 3-[2-[2-[[5-[(3aR,4R,6aS)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]-, rel-;(+)-Biotin-PEG2-acid;Biotin PEG2-C2-COOH;Biotin-PEG2-PA;Biotin-PEG-PA;3-(2-(2-(5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)propanoic acid | | CAS: | 1365655-89-5 | | MF: | C17H29N3O6S | | MW: | 403.5 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1365655-89-5.mol |  |
| | Biotin-PEG2-Acid Chemical Properties |
| Boiling point | 752.2±60.0 °C(Predicted) | | density | 1.234±0.06 g/cm3(Predicted) | | storage temp. | -20°C, protect from light, stored under argon | | solubility | Soluble in DMSO, DMF | | pka | 4.28±0.10(Predicted) | | form | solid | | color | White | | InChIKey | SDOAIZRTYJIBBG-RMBTXETHNA-N | | SMILES | C(O)(=O)CCOCCOCCNC(=O)CCCC[C@@H]1[C@]2([H])NC(=O)N[C@]2([H])CS1 |&1:18,19,25,r| |
| | Biotin-PEG2-Acid Usage And Synthesis |
| Description | Biotin-PEG2-acid is reactive with amine-containing macromolecule. The hydrophilic PEG arm improves water solubility. The biotin groups serve as an affinity label towards the proteins avidin and streptavidin. | | Uses | Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Biotin-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. | | IC 50 | PEGs; Non-cleavable Linker | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
| | Biotin-PEG2-Acid Preparation Products And Raw materials |
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