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| | CBZ-AEP Basic information |
| Product Name: | CBZ-AEP | | Synonyms: | CBZ-AEP;3-[2-(Cbz-amino)ethoxy]propanoic acid;CBZ-NH-PEG1-propionic acid;CBZ-NH-PEG1-acid;inhibit,Cbz NH PEG1 CH2CH2COOH,Inhibitor,PROTAC Linkers,Cbz-NH-PEG-1-CH2CH2COOH,CbzNHPEG1CH2CH2COOH;Propanoic acid, 3-[2-[[(phenylmethoxy)carbonyl]amino]ethoxy]-;3-(2-(((benzyloxy)carbonyl)amino)ethoxy)propanoic acid;Cbz-amine-PEG1-Acid | | CAS: | 1205751-19-4 | | MF: | C13H17NO5 | | MW: | 267.28 | | EINECS: | | | Product Categories: | | | Mol File: | 1205751-19-4.mol |  |
| | CBZ-AEP Chemical Properties |
| Boiling point | 476.2±40.0 °C(Predicted) | | density | 1.225±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Solid | | pka | 4.29±0.10(Predicted) | | color | White to off-white |
| | CBZ-AEP Usage And Synthesis |
| Description | 3-[2-(Cbz-amino)ethoxy]propanoic acid is a PEG linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine. | | Uses | Cbz-NH-PEG1-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | CBZ-AEP Preparation Products And Raw materials |
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