N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine

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Products Intro: Product Name:MC-Val-Ala-OH
CAS:1342211-31-7
Purity:98% Package:1KG;10KG;50KG
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Products Intro: Product Name:Mc-Val-Ala-OH
CAS:1342211-31-7
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Products Intro: Product Name:(S)-2-((S)-2-(6-(2,5-dioxo-2H-pyrrol-1(5H)-yl)hexanamido)-3-methylbutanamido)propanoic acid
CAS:1342211-31-7
Purity:98% Min. Package:5KG;1KG
Company Name: Shanghai Huici Pharmaceutical Technology Co., LTD
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Products Intro: Product Name:MC-Val-Ala-OH
CAS:1342211-31-7
Purity:0.98 Package:1g 5g 25g 50g 100g
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine Basic information
Product Name:N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine
Synonyms:N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine;(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl)-L-valyl-L-alanine;L-Alanine, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-;MC-Val-Ala-OH;(S)-2-((S)-2-(6-(2,5-dioxo-2H-pyrrol-1(5H)-yl)hexanamido)-3-methylbutanamido)propanoic acid
CAS:1342211-31-7
MF:C18H27N3O6
MW:381.42
EINECS:
Product Categories:Linker
Mol File:1342211-31-7.mol
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine Structure
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine Chemical Properties
Boiling point 695.4±50.0 °C(Predicted)
density 1.232±0.06 g/cm3(Predicted)
storage temp. -20°C, sealed storage, away from moisture and light
solubility Soluble in DMSO
pka3.44±0.10(Predicted)
form Solid
color White to off-white
Optical Rotation-41.3128°(C=1.2055g/100ml H2O)
Safety Information
MSDS Information
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine Usage And Synthesis
UsesMC-Val-Ala-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Biological ActivityMC-Val-Ala-OH is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).
in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

IC 50Protease Cleavable Linker; Cleavable Linker
References[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine Preparation Products And Raw materials
Preparation ProductsMC-Val-Ala-PBD
Tag:N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-L-alanine(1342211-31-7) Related Product Information