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| | N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) HCl salt Basic information |
| Product Name: | N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) HCl salt | | Synonyms: | N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) HCl salt;N-(Amino-PEG3)-N-bis(PEG3-Boc);4,7,10,16,19,22-Hexaoxa-13-azapentacosanedioic acid, 13-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-, 1,25-bis(1,1-dimethylethyl) ester;DUN 42629;N-(Amino-PEG3)-N-bis(PEG3-t-butyl) | | CAS: | 2055042-62-9 | | MF: | C34H68N2O13 | | MW: | 712.91 | | EINECS: | | | Product Categories: | | | Mol File: | 2055042-62-9.mol |  |
| | N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) HCl salt Chemical Properties |
| Boiling point | 690.7±50.0 °C(Predicted) | | density | 1.072±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 8.74±0.10(Predicted) |
| | N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) HCl salt Usage And Synthesis |
| Description | N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) is a 3-arm PEG linker consisting of an amino group with two t-butyl esters. The amino (NH2) groups is reactive with activated NHS esters or carboxylic acid. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | N-(Amino-PEG3)-N-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) HCl salt Preparation Products And Raw materials |
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