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Copper(II) gluconate

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CAS:527-09-3
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Copper(II) gluconate manufacturers

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  • Copper Gluconate
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  • 2026-03-20
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Copper(II) gluconate Basic information
Description References
Product Name:Copper(II) gluconate
Synonyms:bis(d-gluconato)-coppe;D-GLUCONIC ACID, COPPER(II) SALT;COPPER(II) GLUCONATE;COPPER(II) D-GLUCONATE;CUPRIC GLUCONATE;COPPER(+2)D-GLUCONATE;COPPER GLUCONATE;GLUCONIC ACID COPPER(II) SALT
CAS:527-09-3
MF:C12H22CuO14
MW:453.84
EINECS:208-408-2
Product Categories:Organometallics;Biochemistry;Classes of Metal Compounds;Cu (Copper) Compounds;Glucose;Sugar Acids;Sugars;Transition Metal Compounds;Chemistry
Mol File:527-09-3.mol
Copper(II) gluconate Structure
Copper(II) gluconate Chemical Properties
Melting point 155-157 °C(lit.)
Boiling point 673.6℃[at 101 325 Pa]
density 1.777[at 20℃]
vapor pressure 13.3Pa at 20℃
refractive index 16.5 ° (C=1, H2O)
storage temp. Inert atmosphere,Room Temperature
solubility Aqueous Acid (Slightly), Water (Sparingly, Sonicated)
form powder
color Light Blue to Blue
Optical Rotation[α]26/D +15°, c = 1 in H2O
Water Solubility slightly soluble
Merck 14,2640
Exposure limitsACGIH: TWA 1 mg/m3
NIOSH: IDLH 100 mg/m3; TWA 1 mg/m3
Stability:Hygrscopic
Cosmetics Ingredients FunctionsSKIN PROTECTING
SKIN CONDITIONING
Cosmetic Ingredient Review (CIR)Copper(II) gluconate (527-09-3)
InChI1S/2C6H12O7.Cu/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
InChIKeyOCUCCJIRFHNWBP-IYEMJOQQSA-L
SMILESOC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O[Cu]OC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
LogP-2.98
CAS DataBase Reference527-09-3(CAS DataBase Reference)
EPA Substance Registry SystemCopper gluconate (527-09-3)
Safety Information
Safety Statements 24/25
WGK Germany 3
RTECS LZ5058000
TSCA TSCA listed
HS Code 29181600
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 2
Skin Sens. 1B
STOT RE 2
Hazardous Substances Data527-09-3(Hazardous Substances Data)
MSDS Information
ProviderLanguage
D-Gluconic acid copper(II) salt English
ACROS English
SigmaAldrich English
ALFA English
Copper(II) gluconate Usage And Synthesis
DescriptionCopper(II) gluconate is the copper salt of D-gluconic acid that is an organic acid. It can be used as a buffer for encapsulating some drugs into liposomes. Copper is an essential microelement for human beings and animals; it is needed to absorb ion from and gut and can help regulate blood pressure and heart rate. It is also a key component of multiple enzymes involved in many biochemical reactions. In this sense, the D-gluconic acid copper (II) salt can be used as a copper supplement to treat the copper deficiency induced anemia and nephrosis. It is also useful in the cancer chemotherapy being capable of enhancing the efficacy of the anticancer drug, disulfiram.
ReferencesDicko, Awa, et al. "Role of copper gluconate/triethanolamine in irinotecan encapsulation inside the liposomes." International Journal of Pharmaceutics 337.1(2007):219-228.
Ferris Iii, Frederick L, et al. "Nutritional supplement to treat macular degeneration.", EP1516542. 2009.
Georgewill Udeme Owunari, Siminialayi Iyeopu Minakiri. “Disulfiram and Copper gluconate in cancer chemotherapy: a review of the literature.” Cancer Research Journal 2.5(2014):88-92.
Chemical PropertiesCopper(II) gluconate, Cu(C6H11O7)2, is a light blue to blue-green, crystalline material that is soluble in water and slightly soluble in ethanol.
UsesSupplement (trace mineral).
Usescopper gluconate is cited as having skin-conditioning and skinprotecting functions.
UsesCopper(II) gluconate is used in dietary supplement. It is also used to treat acne vulgaris, common cold, hypertension, premature labor, leishmaniasis and visceral postoperative complications. Further, it is used in oral deodorants and feed additives. In addition to this, it is used as a synergist and nutritional supplement for foods. It is the active component in retsyn used in mints and certs.
PreparationCopper(II) gluconate is prepared by the dissolution of copper(II) carbonate or copper(II) hydroxide in gluconic acid. It is used as a nutritional supplement for copper deficiency and as a component in oral deodorants.
DefinitionChEBI: Copper gluconate is an organic molecular entity.
Flammability and ExplosibilityNot classified
Safety ProfileWhen heated to decomposition it emits acrid smoke and irritating fumes.
Copper(II) gluconate Preparation Products And Raw materials
Raw materialsCopper(II) sulfate-->Sorbitol-->Cupric oxide-->Calcium gluconate-->Gluconic acid-->Sodium gluconate-->Cupric phosphate trihydrate
Preparation ProductsCOPPER (II) GLUCONATE, MIN. 98
Tag:Copper(II) gluconate(527-09-3) Related Product Information
Manganese gluconate Ferrous gluconate Ferrous fumarate Monosodium fumarate Cupric tartrate Magnesium gluconate Potassium gluconate FERROUS GLUCONATE DIHYDRATE Calcium gluconate Zinc gluconate Glucose oxidase D-(+)-Glucono-1,5-lactone EC 1.1.1.47 CALCIUM GLUCONATE MONOHYDRATE Sodium gluconate Chlorhexidine digluconate D(+)-GLUCOSE MONOHYDRATE COPPER (II) GLUCONATE, MIN. 98