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| | Glycine-15N Basic information |
| | Glycine-15N Chemical Properties |
| Melting point | 240 °C (dec.)(lit.) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Aqueous Base (Slightly, Sonicated, Heated), Water (Sparingly) | | form | Solid | | color | White to Off-White | | BRN | 1853034 | | InChI | 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)/i3+1 | | InChIKey | DHMQDGOQFOQNFH-LBPDFUHNSA-N | | SMILES | [15NH2]CC(O)=O | | CAS Number Unlabeled | 56-40-6 |
| WGK Germany | 3 | | HS Code | 28459000 | | Storage Class | 11 - Combustible Solids |
| | Glycine-15N Usage And Synthesis |
| Chemical Properties | White powder | | Uses | Glycine-15N is the labelled form of Glycine (G615990). Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors. | | Biological Activity | Glycine-15N is the 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1]. | | IC 50 | NMDA Receptor | | References | [1] EDWARD M RUSSAK Edward M B. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals.[J]. Annals of Pharmacotherapy, 2019, 53 2: 211-216. DOI:10.1177/1060028018797110.
[2] W. GREENAWAY F. R W. A convenient synthesis of creatine-15N from glycine-15N via sarcosine-15N[J]. Journal of labelled compounds & radiopharmaceuticals, 1978, 14 4: 611-615. DOI:10.1002/jlcr.2580140417.
[3] HE J, ZHANG X, HE Q, et al. Synthesis of 15N-labeled heterocycles via the cleavage of C–N bonds of anilines and glycine-15N†[J]. Chemical Communications, 2021, 44: 5442-5445. DOI:10.1039/D1CC01734A.
[4] T P STEIN. Measurement of protein synthesis rates with [15N]glycine.[J]. American Journal of Physiology, 1980, 239 4: E294-E300. DOI:10.1152/ajpendo.1980.239.4.E294.
[5] MOSTAFA OTHMAN. Millimeter-Sized Clusters of Triple Cation Perovskite Enables Highly Efficient and Reproducible Roll-to-Roll Fabricated Inverted Perovskite Solar Cells[J]. Advanced Functional Materials, 2021, 32 12. DOI:10.1002/adfm.202110700. |
| | Glycine-15N Preparation Products And Raw materials |
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