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| | 2-Fluoro-6-methoxybenzaldehyde Basic information |
| | 2-Fluoro-6-methoxybenzaldehyde Chemical Properties |
| Melting point | 59-63 °C (lit.) | | Boiling point | 218.5±20.0 °C(Predicted) | | density | 0.807 g/mL at 25 °C | | refractive index | n20/D 1.339 | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | 5 wt.% in methanol | | color | White to tan | | Sensitive | Air Sensitive | | InChI | 1S/C8H7FO2/c1-11-8-4-2-3-7(9)6(8)5-10/h2-5H,1H3 | | InChIKey | UIOAYOIJMYMOEU-UHFFFAOYSA-N | | SMILES | COc1cccc(F)c1C=O | | CAS DataBase Reference | 146137-74-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | UN 1230 3/PG 2 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29130000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Fluoro-6-methoxybenzaldehyde Usage And Synthesis |
| Chemical Properties | off-white crystalline | | Synthesis | General procedure for the synthesis of 2-fluoro-6-methoxybenzaldehyde from m-fluoroanisole and N,N-dimethylformamide: n-butyllithium (1.6 M in hexane, 74.3 ml, 0.118 mol) was added slowly and dropwise to a solution of diisopropylamine (13.23 g, 0.130 mol) in tetrahydrofuran (50 ml) at 0 °C. After maintaining this temperature for 15 min, the reaction system was cooled to -78°C. Subsequently, a tetrahydrofuran (5 ml) solution of 3-fluoroanisole (15 g, 0.118 mol) was added and stirred at -78 °C for 1 hour. Next, N,N-dimethylformamide (6.75 ml) was added and stirring was continued at the same temperature for 1 hour. After completion of the reaction, the reaction was burst with 2N hydrochloric acid solution followed by extraction with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 2-fluoro-6-methoxybenzaldehyde as a red waxy solid (17.45 g, 95% yield), which could be used in subsequent steps without further purification. | | References | [1] Patent: US2012/289496, 2012, A1. Location in patent: Page/Page column 100
[2] Chemistry - A European Journal, 2015, vol. 21, # 29, p. 10322 - 10325
[3] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7499 - 7502
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 12, p. 2998 - 3001
[5] Patent: WO2012/151525, 2012, A1. Location in patent: Page/Page column 100; 101 |
| | 2-Fluoro-6-methoxybenzaldehyde Preparation Products And Raw materials |
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