| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
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| | 4-METHYL-6-CHLORO PYRIMIDINE Basic information |
| | 4-METHYL-6-CHLORO PYRIMIDINE Chemical Properties |
| Melting point | 151-152℃ | | Boiling point | 195℃ | | density | 1.234 | | Fp | 90℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | Solid | | pka | 0.83±0.17(Predicted) | | color | Pale yellow | | Water Solubility | Slightly soluble in water. |
| | 4-METHYL-6-CHLORO PYRIMIDINE Usage And Synthesis |
| Uses | It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. | | Synthesis | To a solution of 4,6-dichloropyrimidine (1.0 g, 6.71 mmol) in tetrahydrofuran (30 mL) was added sequentially 1-methyl-2-pyrrolidinone (3.2 mL, 6.71 mmol), iron(III) acetylacetonate (0.119 g, 0.336 mmol) and methylmagnesium bromide (2.237 mL, 6.71 mmol). The reaction mixture was stirred at room temperature for 3 h. After completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate (100 mL). The organic layer was separated and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: 20% ethyl acetate/hexane) to afford 4-chloro-6-methylpyrimidine (0.6 g, 3.08 mmol, 46% yield) as a colorless gelatinous liquid.LC-MS (ESI) analysis showed m/z 129.0 [M+H]+ (calculated value C5H6ClN2: 129.0); LC/MS retention time ( Method D): 1.36 min. | | References | [1] Patent: WO2017/59085, 2017, A1. Location in patent: Page/Page column 403; 404 |
| | 4-METHYL-6-CHLORO PYRIMIDINE Preparation Products And Raw materials |
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