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| | 2-Chloro-6-methylpyrazine Basic information |
| | 2-Chloro-6-methylpyrazine Chemical Properties |
| Melting point | 49-52 | | Boiling point | 83°C/35mmHg(lit.) | | density | 1.234±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to crystal | | pka | -0.89±0.10(Predicted) | | color | White to Almost white | | InChI | 1S/C5H5ClN2/c1-4-2-7-3-5(6)8-4/h2-3H,1H3 | | InChIKey | CKUVSPQGYLELRG-UHFFFAOYSA-N | | SMILES | Cc1cncc(Cl)n1 |
| Hazard Codes | Xi,Xn | | Risk Statements | 20/21/22-36/37/38-22 | | Safety Statements | 22-26-36/37/39 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 2-Chloro-6-methylpyrazine Usage And Synthesis |
| Chemical Properties | Solid | | Uses | 2-Chloro-6-methylpyrazine was used in the synthesis of palm site inhibitors of HCV NS5B polymerase and potent dipeptidyl peptidase IV inhibitors. | | Synthesis | Step 3: To a 5L sealed reaction tube was added (6-chloropyrazin-2-yl)acetic acid (220 g, 1.27 mol, 1.00 equiv) and deionized water (3L). The reaction mixture was stirred at 130 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently extracted with ether (2 x 3 L). The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 238 g (73% yield) of 2-chloro-6-methylpyrazine as a yellow solid. | | References | [1] Patent: US2015/31674, 2015, A1. Location in patent: Paragraph 0325; 0322 |
| | 2-Chloro-6-methylpyrazine Preparation Products And Raw materials |
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