t-Boc-N-Amido-PEG3-propargyl manufacturers
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| | t-Boc-N-Amido-PEG3-propargyl Basic information |
| Product Name: | t-Boc-N-Amido-PEG3-propargyl | | Synonyms: | t-Boc-N-Amido-PEG3-propargyl;Propargyl-PEG3-NHBoc;Boc-N-Amido-PEG3-Alkyne;5,8,11-Trioxa-2-azatetradec-13-ynoic acid, 1,?1-?dimethylethyl ester;Propargyl-PEG4-Boc Amine;Propargyl-PEG3-NHBoc/5,8,11-Trioxa-2-azatetradec-13-ynoic acid, 1,1-dimethylethyl ester;tert-butyl N-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethyl]carbamate;5,8,1-trioxy-2-aza-13-ynedecatetralkaneacidtertbutyl ester | | CAS: | 1333880-60-6 | | MF: | C14H25NO5 | | MW: | 287.35 | | EINECS: | | | Product Categories: | SiChem | | Mol File: | 1333880-60-6.mol |  |
| | t-Boc-N-Amido-PEG3-propargyl Chemical Properties |
| Boiling point | 386.4±32.0 °C(Predicted) | | density | 1.045±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | Soluble in DMSO, DCM, DMF | | pka | 12.22±0.46(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | t-Boc-N-Amido-PEG3-propargyl Usage And Synthesis |
| Description | t-Boc-N-Amido-PEG3-propargyl enables formation of triazole linkage with azide-bearing compound via copper catalyzed Click Chemistry. Under mild acidic conditions, t-Boc group can be removed to yield the free amine. | | Uses | Boc-NH-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | t-Boc-N-Amido-PEG3-propargyl Preparation Products And Raw materials |
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