t-Boc-N-Amido-PEG8-propargyl manufacturers
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| | t-Boc-N-Amido-PEG8-propargyl Basic information |
| Product Name: | t-Boc-N-Amido-PEG8-propargyl | | Synonyms: | t-Boc-N-Amido-PEG8-propargyl;Boc-NH-PEG8-propargyl;Propargyl-PEG8-NHBoc;Propargyl-PEG9-Boc Amine;Boc-NH-PEG8-Alkyne;Propargyl-PEG8-NHBoc/5,8,11,14,17,20,23,26-Octaoxa-2-azanonacos-28-ynoic acid, 1,1-dimethylethyl ester;5,8,11,14,17,20,23,26-Octaoxa-2-azanonacos-28-ynoic acid, 1,1-dimethylethyl ester;tert-Butyl (3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-yl)carbamate | | CAS: | 2183440-31-3 | | MF: | C24H45NO10 | | MW: | 507.61 | | EINECS: | | | Product Categories: | peg | | Mol File: | 2183440-31-3.mol |  |
| | t-Boc-N-Amido-PEG8-propargyl Chemical Properties |
| Boiling point | 565.0±50.0 °C(Predicted) | | density | 1.076±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 12.23±0.46(Predicted) |
| | t-Boc-N-Amido-PEG8-propargyl Usage And Synthesis |
| Description | t-Boc-N-Amido-PEG8-propargyl has an alkyne group and Boc-protected amine. The alkyne group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The deprotection of Boc-protected amine can be peformed under mild acidic conditions. The hydrophilic PEG chain enhances the solubility of the molecule in aqueous solution. | | Uses | Boc-NH-PEG8-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG8-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | t-Boc-N-Amido-PEG8-propargyl Preparation Products And Raw materials |
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