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| | Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Basic information |
| Product Name: | Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine | | Synonyms: | N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-(1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL)-L-2,3-DIAMINOPROPIONIC ACID;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-BETA-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL]-L-2,3-DIAMINOPROPIONIC ACID;N-ALPHA-FMOC-N-BETA-1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-DIAMINOPROPIONIC ACID;3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine;FMOC-N-BETA-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-2,3-DIAMINOPROPIONIC ACID;FMOC-DPR(IVDDE)-OH;FMOC-L-DAP(IVDDE)-OH;(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)propanoic acid | | CAS: | 607366-20-1 | | MF: | C31H36N2O6 | | MW: | 532.63 | | EINECS: | | | Product Categories: | amino acid;amino acids | | Mol File: | 607366-20-1.mol | ![Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Structure](CAS/GIF/607366-20-1.gif) |
| | Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Chemical Properties |
| Boiling point | 733.7±60.0 °C(Predicted) | | density | 1.221 | | storage temp. | Store at -15°C to -25°C. | | pka | 3.47±0.10(Predicted) | | form | powder | | Appearance | White to off-white Solid | | Major Application | peptide synthesis | | InChIKey | HLIFXCXTXPXGNH-VWLOTQADSA-N | | SMILES | N([C@@H](CNC(=C4C(=O)CC(CC4=O)(C)C)CC(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3 |
| WGK Germany | WGK 2 | | HS Code | 2924297099 | | Storage Class | 11 - Combustible Solids |
| | Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Usage And Synthesis |
| Uses | N-alpha-Fmoc-N-beta-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic Acid is used in the synthesis of phenylpyrazolo[3,4-d]pyrimidine-peptide conjugates as Src kinase inhibitors. It is also used to prepare peptidomimetic ligands for α4β1 integrin on Jurkat T-leukemia cells. | | General Description | This orthogonally-protected diaminopropionic acid derivative is based on the hindered Dde variant ivDde. The side-chain ivDde group is considerably more stable to piperidine than Dde and is less prone to migrate from protected to unprotected side-chains [1]. However, migration from side-chain to the unprotected α-amino group of Dpr is unavoidable [2]. This side-reaction can, however, be minimized by the appropriate choice of coupling method for the subsequent residue, see [3].
When removing ivDde in the presence of allyl-based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group [4].
The product number for this product was previously 04-12-1195.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”. | | reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
| | Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Preparation Products And Raw materials |
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