- 2,5-Difluorotoluene
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- $1.00 / 1KG
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2019-07-06
- CAS:452-67-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg,5kg,100kg
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| | 2,5-Difluorotoluene Basic information |
| Product Name: | 2,5-Difluorotoluene | | Synonyms: | 1,4-Difluoro-2-methylbenzene;Benzene, 1,4-difluoro-2-methyl-;2,5-Difluorotolune;2 5-DIFLUOROTOLUENE 98%;2,5-Difluorotoluene,98%;2,5-DIFLUOROTOLUENE;2,5-Difluorotoluene, 99.5+%;2,5-Difluorotoluene, 99+% | | CAS: | 452-67-5 | | MF: | C7H6F2 | | MW: | 128.12 | | EINECS: | 207-205-6 | | Product Categories: | Aromatic Hydrocarbons (substituted) & Derivatives;Halogen toluene;Miscellaneous;Fluorinated benzene series;Fluorin-contained toluene series | | Mol File: | 452-67-5.mol |  |
| | 2,5-Difluorotoluene Chemical Properties |
| Melting point | -35°C | | Boiling point | 117 °C775 mm Hg(lit.) | | density | 1.36 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.452(lit.) | | Fp | 55 °F | | storage temp. | 2-8°C | | form | liquid | | color | Clear, colourless | | Specific Gravity | 1.360 | | BRN | 2041492 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | CAS DataBase Reference | 452-67-5(CAS DataBase Reference) | | NIST Chemistry Reference | 2,5-Difluorotoluene(452-67-5) |
| Hazard Codes | F,F+ | | Risk Statements | 11 | | Safety Statements | 16-29-33 | | RIDADR | UN 1993 3/PG 2 | | WGK Germany | 3 | | Hazard Note | Flammable | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29039990 |
| | 2,5-Difluorotoluene Usage And Synthesis |
| Chemical Properties | colorless to light yellow liqui | | Uses | 2,5-Difluorobenzaldehyde is a very important fine chemical. It is an intermediate for the synthesis of many important chemicals and is used as an intermediate for medicines, pesticides, and liquid crystal materials.
| | Synthesis | General procedure for the synthesis of p-fluorotoluene, 2-fluorotoluene, 3-fluorotoluene, 2,4-difluorotoluene, 2,5-difluorotoluene, and 1,2-difluoro-4-methylbenzene from toluene: To a glass reactor fitted with a PTFE-lined magnetic stirring bar connected to a gas scrubbing flask, add toluene (0.95-1.14 mmol), acetonitrile (1-2.5 mL/mmol toluene ) and boron trifluoride ethyl ether complex (1.3-1.6 mmol/mmol toluene). The reaction solution was stirred at -25 °C for 10-15 min, followed by the addition of xenon difluoride (1.2-1.3 mmol/mmol toluene) in batches. The reaction mixture was slowly warmed to 22 °C over 1 h and stirring was continued for 40-60 min. Upon completion of the reaction, hexafluorobenzene was added as an internal standard and samples were taken for 19F NMR analysis (Method B). The reaction mixture was quenched with saturated aqueous sodium bicarbonate and extracted with dichloromethane (1-2 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and subsequently analyzed by 19F NMR and GC/MS (Procedure C). The major products are listed in the table and the remaining products are listed below (GC/MS data). | | References | [1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 10, p. 1400 - 1407
[2] Zh. Org. Khim., 2016, vol. 52, # 10, p. 1412 - 1419,8 |
| | 2,5-Difluorotoluene Preparation Products And Raw materials |
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