3-Bromo-2-hydroxy-5-nitropyridine manufacturers
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| | 3-Bromo-2-hydroxy-5-nitropyridine Basic information |
| | 3-Bromo-2-hydroxy-5-nitropyridine Chemical Properties |
| Melting point | 213-218℃ | | Boiling point | 300.9±42.0 °C(Predicted) | | density | 1.98±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 6.58±0.10(Predicted) | | form | Solid | | color | White to Light yellow | | InChI | InChI=1S/C5H3BrN2O3/c6-4-1-3(8(10)11)2-7-5(4)9/h1-2H,(H,7,9) | | InChIKey | KWSOHRDMTWDAOI-UHFFFAOYSA-N | | SMILES | C1(=O)NC=C([N+]([O-])=O)C=C1Br |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | IRRITANT, KEEP COLD | | HS Code | 2933399990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
| | 3-Bromo-2-hydroxy-5-nitropyridine Usage And Synthesis |
| Uses | 3-Bromo-2-hydroxy-5-nitropyridine is used widely in fields such as medicine, agricultural chemicals and organic syntheses. | | Synthesis | General procedure for the synthesis of 3-bromo-2-hydroxy-5-nitropyridine from 2-hydroxy-5-nitropyridine:
Step 1: A mixture of 2-hydroxy-5-nitropyridine (50 g, 0.358 mol) and water (7 L) was heated to 40 °C, followed by the slow dropwise addition of bromine (21 mL, 0.393 mol) over 20 min. The reaction mixture was cooled to 10 °C after continuous stirring at 40 °C for 2.5 hours. The crude product was separated by filtration and the solid was washed with water and dried under vacuum to give 70 g of 3-bromo-2-hydroxy-5-nitropyridine as a solid (90% yield). The product had a melting point of 212-214 °C (accompanied by decomposition); 1H NMR (CD3OD) δ 8.66 (d, J = 2.9 Hz, 1H), 8.64 (d, J = 2.9 Hz, 1H). | | References | [1] Patent: WO2015/92011, 2015, A1. Location in patent: Page/Page column 31 [2] Patent: WO2009/21696, 2009, A1. Location in patent: Page/Page column 42 [3] Patent: US2006/79522, 2006, A1. Location in patent: Page/Page column 8; 12-13 [4] Patent: US2006/79523, 2006, A1. Location in patent: Page/Page column 9; 13 [5] Patent: US2006/79524, 2006, A1. Location in patent: Page/Page column 9; 13 |
| | 3-Bromo-2-hydroxy-5-nitropyridine Preparation Products And Raw materials |
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