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| | 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL Basic information |
| Product Name: | 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL | | Synonyms: | 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL;5-AMINO-2-METHOXY-3-PICOLINE HCL;5-AMINO-2-METHOXY-3-PICOLINE HYDROCHLORIDE;6-methoxy-5-methylpyridin-3-amine;6-Methoxy-5-methyl-3-pyridinamine;2-methoxy-3-methyl-5-aminopyridine;3-Amino-6-methoxy-5-methylpyridine 97%;6-Methoxy-5-me6-Methoxy-5-methylpyridin-3-aminethylpyridin-3-amine | | CAS: | 867012-70-2 | | MF: | C7H10N2O | | MW: | 138.17 | | EINECS: | | | Product Categories: | Heterocyclic Compounds | | Mol File: | 867012-70-2.mol |  |
| | 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL Chemical Properties |
| Melting point | 53-57°C | | Boiling point | 268℃ | | density | 1.103 | | Fp | 116℃ | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | solid | | pka | 4.62±0.20(Predicted) | | Appearance | Pale purple to purple Powder | | InChI | 1S/C7H10N2O/c1-5-3-6(8)4-9-7(5)10-2/h3-4H,8H2,1-2H3 | | InChIKey | RFEMLHVKBYMWAM-UHFFFAOYSA-N | | SMILES | COc1ncc(N)cc1C |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 3-amino-6-methoxy-5-methylpyridine from 2-methoxy-5-nitro-3-methylpyridine: (1c) 6-methoxy-5-methyl-3-pyridinamine [Eq. 10]; 2-methoxy-3-methyl-5-nitro-pyridine (1.63 g, 9.71 mmol) was dissolved in methanol (50 mL), 10% Pd/C catalyst was added (50% water content, 800 mg) and the reaction was stirred under hydrogen atmosphere for 2 h 10 min. Upon completion of the reaction, it was filtered through diatomaceous earth and the solvent was evaporated to afford 3-amino-6-methoxy-5-methylpyridine (1.25 g, 9.0 mmol, 93% yield) as a blue oil.1H NMR (400 MHz, DMSO-d6) δ ppm: 2.03 (3H, s), 3.73 (3H, s), 4.62 (2H, s), and 6.83-6.86 (1H, m), 7.31-7.34 (1H, m). | | References | [1] Patent: WO2005/103049, 2005, A1. Location in patent: Page/Page column 63-64
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3056 - 3062 |
| | 5-AMINO-2-METHOXY-3-METHYLPYRIDINE HCL Preparation Products And Raw materials |
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