- 2-Nitro-3-pyridinol
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- $200.00 / 1KG
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2025-09-25
- CAS:15128-82-2
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
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| | 3-Hydroxy-2-nitropyridine Basic information |
| | 3-Hydroxy-2-nitropyridine Chemical Properties |
| Melting point | 69-71 °C (lit.) | | Boiling point | 256.56°C (rough estimate) | | density | 1.5657 (rough estimate) | | refractive index | 1.4800 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | form | Crystalline Powder | | pka | 0.31±0.22(Predicted) | | color | Yellow | | BRN | 124473 | | InChI | InChI=1S/C5H4N2O3/c8-4-2-1-3-6-5(4)7(9)10/h1-3,8H | | InChIKey | QBPDSKPWYWIHGA-UHFFFAOYSA-N | | SMILES | C1([N+]([O-])=O)=NC=CC=C1O | | CAS DataBase Reference | 15128-82-2(CAS DataBase Reference) | | EPA Substance Registry System | 3-Hydroxy-2-nitropyridine (15128-82-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-36 | | WGK Germany | 3 | | RTECS | UU7715000 | | Hazard Note | Irritant | | HS Code | 29333990 | | Toxicity | mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04089, |
| | 3-Hydroxy-2-nitropyridine Usage And Synthesis |
| Chemical Properties | yellow crystalline powder | | Uses | 3-Hydroxy-2-nitropyridine may be used in the synthesis of novel sulfonates that are potent inhibitors of cell proliferation and tubulin polymerization. | | Preparation | Synthesis of 3-hydroxy-2-nitropyridine: add 10g of 3-hydroxypyridine, 80ml of ethyl acetate, 4.2g of KNO3 and 21ml of acetic anhydride into a 250mL three-necked flask, and heat at 45°C with magnetic stirring After the reaction is completed, it is cooled to room temperature, filtered with suction, washed with a small amount of ethyl acetate for 1 to 2 times, the filtrate is taken to adjust the pH to neutrality with saturated NaOH solution, and extracted with ethyl acetate for 3 to 4 times. , take the extract and add activated carbon and heat under reflux for 1 hour, cool and filter, take the filtrate, dry with anhydrous magnesium sulfate, filter, concentrate on a rotary evaporator, and dry in a drying oven. 11.9 g of 3-hydroxy-2-nitropyridine was obtained with a yield of 81%. |
| | 3-Hydroxy-2-nitropyridine Preparation Products And Raw materials |
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