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| | (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone Basic information |
| | (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone Chemical Properties |
| Melting point | 42-44 °C | | alpha | 97 º (c=1, EtOH) | | Boiling point | 375.51°C (rough estimate) | | density | 1.1475 (rough estimate) | | refractive index | 103 ° (C=1, EtOH) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform, Methanol | | form | Solid | | pka | -2.35±0.40(Predicted) | | color | Off-White to Pale Yellow | | Optical Rotation | [α]20/D +97°, c = 1 in ethanol | | InChI | InChI=1S/C13H15NO3/c1-2-12(15)14-11(9-17-13(14)16)8-10-6-4-3-5-7-10/h3-7,11H,2,8-9H2,1H3/t11-/m0/s1 | | InChIKey | WHOBYFHKONUTMW-NSHDSACASA-N | | SMILES | O1C[C@H](CC2=CC=CC=C2)N(C(=O)CC)C1=O | | CAS DataBase Reference | 101711-78-8(CAS DataBase Reference) |
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| | (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone Usage And Synthesis |
| Chemical Properties | Colourless Solid | | Uses | Versatile chiral auxiliary for asymmetric synthesis. | | Uses | Intermediate in the preparation of Albaconazole. | | Synthesis | Under nitrogen atmosphere, (S)-4-benzyl-2-azolidinone (800 mg, 4.5 mmol) was dissolved in a dry reaction vial of anhydrous tetrahydrofuran (30 mL) and cooled to -78 °C in a dry ice/acetone bath. A hexane solution of 1.6 M n-butyllithium (5.0 mmol, 3.1 mL) was added slowly and dropwise over 3 min. After stirring for 30 min, propionyl chloride (5.0 mmol, 0.43 mL) was added dropwise over 3 min. The reaction solution was slowly warmed to room temperature over 14 h. The reaction was subsequently quenched by the addition of saturated ammonium chloride solution (10 mL) and water (30 mL). The aqueous layer was extracted with ethyl acetate (3 x 40 mL), the organic phases were combined and dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford (R)-(-)-benzyl-3-propionyl-2-oxazolidinone (oil, 1.0 g, 96% yield) with >95% purity by HPLC.1H NMR (500 MHz, CDCl3): δ7.33 (dd, J1=7.4 Hz, J2=7.6 Hz, 2H), 7.29 (d, J=6.9 Hz, 1H), 7.21 (d, J=7.4 Hz, 2H), 4.67 (m, 1H), 4.18 (m, 2H), 3.31 (dd, J1=13.3 Hz, J2=3.2 Hz, 1H), 2.96 (m, 2H), 2.77 (dd, J1=13.3 Hz, J2=3.7 Hz, 1H), 1.21 (t, J=7.4 Hz, 3H). | | References | [1] Chemistry - An Asian Journal, 2011, vol. 6, # 7, p. 1791 - 1799
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 144 - 148
[3] Journal of Organic Chemistry, 2008, vol. 73, # 8, p. 3292 - 3294
[4] Angewandte Chemie - International Edition, 2016, vol. 55, # 13, p. 4252 - 4255
[5] Angew. Chem., 2016, vol. 128, # 13, p. 4324 - 4327,4 |
| | (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone Preparation Products And Raw materials |
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