- 3-Bromo-5-methoxypyridine
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- $200.00 / 1KG
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2025-09-25
- CAS:37669-64-0
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
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| | 5-Bromo-3-pyridinemethanol Basic information |
| | 5-Bromo-3-pyridinemethanol Chemical Properties |
| Melting point | 27° | | Boiling point | 291.5±25.0 °C(Predicted) | | density | 1.67 | | refractive index | 1.5940-1.5980 | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 13.29±0.10(Predicted) | | form | Liquid or Low Melting Solid | | color | Clear pale yellow | | InChIKey | WDVDHJLKXYCOFS-UHFFFAOYSA-N |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2933399990 |
| | 5-Bromo-3-pyridinemethanol Usage And Synthesis |
| Synthesis |
Sodium borohydride (2.2 g, 59.1 mmol) was added to a suspension of 5-bromo-pyridine-3-carbaldehyde (10.0 g, 53.7 mmol) in MeOH (100 mL) at 0° C. The mixture was stirred at 0° C. for 1 hour before it was quenched by adding water (5.0 mL). Evaporation of solvents afforded a light yellowish oil, which was re-dissolved in EtOAc and washed with water. The organic layer was dried over anhy. Na2SO4, filtered and concentrated in vacuo to give 5-Bromo-3-pyridinemethanol (9.6 g, 95 per cent) as a colourless oil.
| | References | [1] Patent: WO2013/79452, 2013, A1. Location in patent: Page/Page column 143
[2] Patent: US2013/143863, 2013, A1. Location in patent: Paragraph 1076; 1077; 1078
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 10, p. 4913 - 4925
[4] Patent: US2013/267495, 2013, A1. Location in patent: Paragraph 0454-0455
[5] Patent: US2013/296302, 2013, A1. Location in patent: Paragraph 0549 |
| | 5-Bromo-3-pyridinemethanol Preparation Products And Raw materials |
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