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| | 2-Amino-1,3-benzenediol Basic information |
| Product Name: | 2-Amino-1,3-benzenediol | | Synonyms: | 6-BROMO-2,4-DIETHOXY-1-NITROBENZENE;2-Aminoresorcinol;2-amino-1,3-benzenediol;o-aminoresorcinol;1,3-Benzenediol, 2-amino-;2-amino-1,3-dihydroxybenzene;2-aMinobenzene-1,3-diol | | CAS: | 3163-15-3 | | MF: | C6H7NO2 | | MW: | 125.13 | | EINECS: | 926-781-6 | | Product Categories: | | | Mol File: | 3163-15-3.mol |  |
| | 2-Amino-1,3-benzenediol Chemical Properties |
| Melting point | >200 °C (decomp) | | Boiling point | 292.8±30.0 °C(Predicted) | | density | 1.412±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 9.24±0.10(Predicted) | | Appearance | Light brown to khaki Solid |
| | 2-Amino-1,3-benzenediol Usage And Synthesis |
| Synthesis | (1) 2-Nitroresorcinol (1.00 g, 6.45 mmol) was dissolved in ethanol (10 mL). 10% Pd/C catalyst (340 mg, 0.32 mmol) was added to the solution at room temperature and under hydrogen atmosphere and the reaction was stirred for 6 hours. Upon completion of the reaction, the insoluble material was removed by filtration and the solvent was subsequently removed by distillation under reduced pressure to afford the brown crystalline product 2-aminoresorcinol 779 mg in 97% yield. Melting point: 153-155 °C (decomposition).1H NMR (CD3OD/CDCl3 = 1/20, 400 MHz) δ: 6.37 (2H, d, J = 8 Hz), 6.54 (1H, t, J = 8 Hz). | | References | [1] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0089
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 2186 - 2197
[3] Journal of Medicinal Chemistry, 1992, vol. 35, # 21, p. 3792 - 3802
[4] Patent: WO2005/54249, 2005, A1. Location in patent: Page/Page column 24
[5] European Journal of Medicinal Chemistry, 2010, vol. 45, # 9, p. 3531 - 3540 |
| | 2-Amino-1,3-benzenediol Preparation Products And Raw materials |
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