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Methoxyverapamil hydrochloride manufacturers
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| | Methoxyverapamil hydrochloride Basic information |
| Product Name: | Methoxyverapamil hydrochloride | | Synonyms: | (+/-)-VERAPAMIL, METHOXY-, HYDROCHLORIDE;VERAPAMIL, (+/-)-METHOXY-, HYDROCHLORIDE;(+/-)-ALPHA-(3-[(2-[3,4-DIMETHOXYPHENYL]ETHYL)METHYLAMINO]PROPYL)-3,4,5-TRIMETHOXY-ALPHA-(1-METHYLETHYL)-BENZENEACETONITRILE HYDROCHLORIDE;D600;D600, HCL;D 600 HYDROCHLORIDE;[3-cyano-3-(3,4,5-trimethoxyphenyl)hex-6-yl]-(5,6-dimethoxyphenethyl)methylammonium chloride;GALLOPAMIL HYDROCHLORIDE | | CAS: | 16662-46-7 | | MF: | C28H41ClN2O5 | | MW: | 521.09 | | EINECS: | 2407047 | | Product Categories: | | | Mol File: | 16662-46-7.mol |  |
| | Methoxyverapamil hydrochloride Chemical Properties |
| Melting point | 145-148° | | storage temp. | Store at -20°C | | solubility | DMF: 16.7 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.25 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | Methoxyverapamil hydrochloride Usage And Synthesis |
| Description | Gallopamil hydrochloride is a somewhat more potent methoxy analog of calcium
channel blocker verapamil with a similar profile. It is useful in the treatment of
angina and auricular arrhythmia. | | Originator | Knoll (W. Germany) | | Uses | Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3]. | | Brand name | Benpredil;Corapamil;PROCORUM. | | in vivo | Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate[3].
| Animal Model: | Male Wistar rats weighing 290-370 g[3] | | Dosage: | 0.2 mg/kg | | Administration: | i.v.; 5 min | | Result: | Markedly reduced VT and totally prevented VF.
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| | References | [1] Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. DOI:10.2165/00003495-199447010-00007
[2] Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. DOI:10.1159/000137824
[3] Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21. DOI:10.1111/j.1440-1681.1991.tb01434.x |
| | Methoxyverapamil hydrochloride Preparation Products And Raw materials |
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